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STK25 encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. Additionally we are shipping STK25 Antibodies (65) and many more products for this protein.
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STK25 regulates lipid partitioning in human liver cells by controlling TAG synthesis as well as lipolytic activity and thereby NEFA (show NUCB2 Proteins) release from lipid droplets for beta-oxidation and TAG secretion.
Our results suggest that MST4 (show MST4 Proteins), STK25 and PDCD10 (show PDCD10 Proteins) are upregulated in prostate cancer and may play roles in prostate tumorigenesis.
This review notes that all 3 human germinal center kinase (show MAP4K2 Proteins) III genes consist of 12 exons and are ubiquitously expressed. In SOK1 and MST4 (show MST4 Proteins), exon 1 encodes a 5' untranslated region, but this is not the case for MST3 (show STK24 Proteins).
Down-modulation of STK25, but not STK24 (show STK24 Proteins), rescued medulloblastoma cells from NGF (show NGFB Proteins)-induced TrkA (show NTRK1 Proteins)-dependent cell death, suggesting that STK25 is part of the death-signaling pathway initiated by TrkA (show NTRK1 Proteins) and CCM2 (show CCM2 Proteins).
PDCD10 (show PDCD10 Proteins) might be a regulatory adaptor required for STK25 functions, which differ distinctly depending on the redox status of the cells that may be potentially related to tumor progression.
Significantly higher STK25 levels were observed in the skeletal muscle of type 2 diabetic patients, compared with individuals with normal glucose tolerance.
The results of the study results indicate that attenuation of SOK1 enhanced cell migration and lead to changes in the expression of migration-associated proteins such as FAK (show PTK2 Proteins) and GM130 (show GOLGA2 Proteins).
In cultured human endothelial cells, CCM3 (show PDCD10 Proteins) and STK25 regulated barrier function in a manner similar to CCM2 (show CCM2 Proteins), and STKs negatively regulated Rho by directly activating moesin (show MSN Proteins).
14-3-3zeta (show YWHAZ Proteins) is a specific substrate for YSK1 that localizes to the Golgi apparatus, and potentially links YSK1 signaling at the Golgi apparatus with protein transport.
Ste20 (show STK24 Proteins) family member (MAP4K3 (show MAP4K3 Proteins)) that is required for maximal S6K (S6 kinase (show RPS6KB1 Proteins))/4E-BP1 (show EIF4EBP1 Proteins) [eIF4E (eukaryotic initiation factor 4E (show EIF4E Proteins)) that is required for maximal S6K (S6 kinase (show RPS6KB1 Proteins)).
a significant positive correlation in human liver biopsies between STK25 expression and nonalcoholic steatohepatitis development
we challenged Stk25 knockout and wild-type mice with a high-fat diet and showed that STK25 deficiency suppressed development of hyperglycemia and hyperinsulinemia, improved glucose tolerance, reduced liver gluconeogenesis and increased insulin (show INS Proteins) sensitivity
Stk25 transgenic mice challenged with a high-fat diet displayed a dramatic increase in liver steatosis and hepatic insulin (show INS Proteins) resistance compared to wild-type siblings.
Loss of Stk25 function early in development likely leads to functional compensation for its roles in neuronal development.
Findings suggest that overexpression of STK25 in conditions of excess dietary fuels associates with a shift in the metabolic balance in peripheral tissues from lipid oxidation to storage, leading to a systemic insulin (show INS Proteins) resistance.
Stk25 is a genetic modifier of Tau phosphorylation in Dab1 (show DAB1 Proteins)-mutant mice.
This demonstrates that the balance between Reelin (show RELN Proteins)-Dab1 (show DAB1 Proteins) signaling and LKB1 (show STK11 Proteins)-Stk25-GM130 (show GOLGA2 Proteins) regulates Golgi dispersion, axon specification, and dendrite growth and provides insights into the importance of the Golgi apparatus for cell polarization.
Mst3b (show STK24 Proteins) regulates axon regeneration in both CNS and PNS neurons in Nervous System Diseases.
Confirmed Hdlq14 as a separate independent quantitative trait locus for HDL (show HSD11B1 Proteins) and narrowed the region to 2 genes, Farp2 (show FARP2 Proteins) and Stk25, with considerable evidence for both.
This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene.
Ste20, yeast homolog
, serine/threonine-protein kinase 25
, ste20-like kinase
, ste20/oxidant stress response kinase 1
, sterile 20/oxidant stress-response kinase 1
, serine/threonine kinase 25 (STE20 homolog, yeast)
, Ste20-like kinase
, Yeast Sps1/Ste20-related kinase 1
, serine/threonine kinase 25 (Ste20, yeast homolog)