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Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]..
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Overexpression of STYK1 was significantly associated with increased cell proliferation, migratory capability, and invasive capability in vitro, as well as increased volume of tumor, weight of tumor, and number of pulmonary metastasesin hepatocellular carcinoma.
STYK1 plays an important role in glioma development and progression.
Findings show that serine-threonine-tyrosine kinase 1 (NOK) mediates glycolysis and nuclear pyruvate dehydrogenase (show PDP ELISA Kits) complex (PDC (show PNKD ELISA Kits)) associated histone acetylation.
Survival analysis reveals that STYK1 level is an independent prognostic factor for nasopharyngeal carcinoma patients. Our results indicate that STYK1 is a promising therapeutic target in nasopharyngeal carcinoma
Thus, our results reveal a novel tumorigenic function of NOK to mediate the genesis and remodeling of blood and lymphatic vessels during tumor progression.
High STYK1 expression is associated with intrahepatic cholangiocarcinoma.
increased STYK1 protein expression correlates with disease progression and metastasis and may serve as a predictor of poor survival in CRC (show CALR ELISA Kits).
The data indicates that both P203 and V395 residues on NOK are important for NOK mediated mitogenic signaling.
NOK expression increased in renal cell carcinoma and was significantly correlated with TNM stage, Fuhrman grade, poor overall survival, poor disease-free survival, metastasis, and proliferation.
STYK1/NOK is dramatically upregulated in colorectal cancer tissues and could be used as a tumor marker. Furthermore, the high expression of STYK1/NOK is significantly associated with tumor size.
Point mutations at either Y327 or Y356 dramatically blocked cellular transformation by NOK as examined by colony formation and cellular DNA synthesis.
Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004
, serine/threonine/tyrosine kinase 1
, tyrosine-protein kinase STYK1-like
, novel oncogene with kinase domain
, protein PK-unique
, tyrosine-protein kinase STYK1
, NOK kinase