serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) ELISA Kits

The protein encoded by SERPINA1 is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Additionally we are shipping SERPINA1 Antibodies (436) and SERPINA1 Proteins (53) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SERPINA1 5265 P01009
SERPINA1 24648 P17475
SERPINA1    
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Top SERPINA1 ELISA Kits at antibodies-online.com

Showing 10 out of 45 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 2.83 ng/mL 6.25 ng/mL - 400 ng/mL 96 Tests 13 to 16 Days
$700.00
Details
Rat 3.5 ng/mL 7.81 ng/mL - 500 ng/mL 96 Tests 13 to 16 Days
$760.00
Details
Mouse 13.7 ng/mL 31.2 ng/mL - 2000 ng/mL 96 Tests 13 to 16 Days
$720.00
Details
Cow 19.5 ng/mL 78.125-5000 ng/mL Typical standard curve 96 Tests 15 to 18 Days
$788.33
Details
Human 0.18 ng/mL 0.55 ng/mL - 400 ng/mL 96 Tests 13 to 16 Days
$884.21
Details
Pig 0.58 0.58   96 Tests 15 to 18 Days
$1,026.67
Details
Rabbit 1.0 ng/mL 10-250 ng/mL   96 Tests 15 to 18 Days
$707.14
Details
Guinea Pig 1.0 ng/mL 10-250 ng/mL   96 Tests 15 to 18 Days
$707.14
Details
Monkey 1.0 ng/mL 5-100 ng/mL   96 Tests 15 to 18 Days
$707.14
Details
Dog 1.0 ng/mL 10-250 ng/mL   96 Tests 15 to 18 Days
$707.14
Details

Top referenced SERPINA1 ELISA Kits

  1. Human SERPINA1 ELISA Kit for Sandwich ELISA - ABIN414796 : Zhang, Shi, Jiang, Stupak, Ou, Qiu, An, Li, Yang: Expression and characterization of recombinant human alpha-antitrypsin in transgenic rice seed. in Journal of biotechnology 2013 (PubMed)
    Show all 3 Pubmed References

  2. Rat (Rattus) SERPINA1 ELISA Kit for Sandwich ELISA - ABIN416538 : Wang, Du, Yu, Bai, Zhao, Wang, Zhu, Feng, Gao, Zhao, Liu: Hepatic steatosis depresses alpha-1-antitrypsin levels in human and rat acute pancreatitis. in Scientific reports 2015 (PubMed)

More ELISA Kits for SERPINA1 Interaction Partners

Human serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) interaction partners

  1. Liver steatosis and impaired lipid secretion occurs in adults with alpha-1-antitrypsin deficiency caused by the Pi*ZZ mutation.

  2. the identification and characterisation of the novel AAT reactive centre loop variant Gly349Arg (p.G373R), is reported.

  3. serum level of oxidized A1AT would be potentially good biomarker for the assessment of harmful effect of smoking to the onset and severity of COPD

  4. Study demonstrates that physiological concentrations of human anti-protease alpha-1 antitrypsin (AAT) efficiently inhibit ATP-induced release of IL-1beta from primary human blood mononuclear cells, monocytic U937 cells, and rat lung tissue, whereas ATP-independent IL-1beta release is not impaired. Results suggest that AAT controls ATP-induced IL-1beta release from human mononuclear blood cells by a novel signaling path...

  5. We addressed these issues for alpha-1-antitrypsin deficiency, a disease mediated by mutations in the SERPINA1 gene encoding alpha-1-antitrypsin. We compiled a comprehensive database of SERPINA1 coding mutations and assigned them apparent pathological relevance based upon available data.

  6. Missense variants of SERPINA1 in the alpha-1 antitrypsin deficiency patients.

  7. Slightly ncreased AAT Activity is associated with Idiopathic Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension

  8. Report that - 10T/C SNP present in hepatocyte-specific promoter present in exon 1C of the SERPINA1 gene may be associated with the decreased levels of circulating alpha1AT in COPD patients of Kashmiri Ancestry.

  9. In this study, two CRISPR/Cas9 gene editing approaches were used to decrease liver aggregates and increase systemic AAT-M levels in the PiZ transgenic mouse. In the first approach, AAT expression in hepatocytes was reduced more than 98% following the systemic delivery of AAV8-CRISPR targeting exon 2 of hSERPINA1, leading to reduced aggregates in hepatocytes.

  10. This study demonstrates a proof of concept for the application of CRISPR-Cas9 technology to correct AAT mutations in vivo and validates continued exploration of this approach for the treatment of patients with AAT deficiency.

  11. ERdj3 expression is enhanced in hepatocellular carcinoma (HCC) tumors and is positively associated with more inferior survival outcomes. ERdj3 promotes intracellular Z mutant of alpha-1-antitrypsin (AATZ) accumulation in HCC cells via suppressing post-transcriptional AATZ degradation and promotes HCC cell proliferation, epithelial-mesenchymal transition, migratory ability and invasiveness in an AATZ-dependent manner.

  12. A new alpha-1-antitrypsin null allele (PI*Q0la palma) that combines two defective genetic variants was characterized.

  13. Alpha-1 Antitrypsin Deficiency patients, who had a mutation requiring exon sequencing for identification were numerically younger (52 +/- 11 vs. 55 +/- 11 yr), had a more severe deficit (alpha-1 antitrypsin levels) and a lower post-bronchodilator forced expiratory volume in 1 second.

  14. The DOM-7 functionally inhibits neutrophil elastase (ELANE) and chymotrypsin, and therefore needs to be considered when aiming at the generation of A1AT-deficient models.

  15. We generated weighted polygenic risk score (PRS) based on 6 genome-wide significant SNPs (rs11621961, rs11629171, rs7161521, rs2749527, rs3762132, rs4900229). salivary cortisol increased in the high PRS group. It remained unchanged in low PRS group. These results were mainly driven by minor alleles of rs7161521 (SERPINA6) and rs4900229 (SERPINA1).

  16. The genotype MZ (heterozygous alpha-1-antitrypsin Z allele) is a genetic risk factor for more advanced cirrhosis and decompensation. MZ patients with cirrhosis and hypotransferrinemia or increased transferrin saturation are at higher risk of death and liver transplantation.

  17. Assays. These results provide the first evidence of intracellular co-polymerization of AAT mutants and contribute to understanding the risk of liver disease in SZ and MZ heterozygotes.

  18. Review of the characteristics of 8 cases of alpha-1 antitrypsin deficiency associated with the genetic variant PI*Mpalermo in Spain.

  19. The abnormal alleles Pi*S and Pi*Z of the SERPINA1 gene may affect the clinical course of granulomatosis with polyangiitis

  20. The results do not support a role of SERPINA1 gene methylation as determinant of lung function across the life course in the tobacco smoke exposed general population exposed.

Chimpanzee serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) interaction partners

  1. The mechanism underlying the alpha(1)PI deficiency that attends HIV-1 infection, was investigated.

Cow (Bovine) serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1) interaction partners

  1. Comparisons of the expression patterns of cattle fetuses and their dams show that the PI gene is biallelically expressed in fetuses and predominantly monoallelically expressed in the dams.

SERPINA1 Antigen Profile

Antigen Summary

The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with SERPINA1

  • alpha-1-antiproteinase F precursor (LOC100008973) antibody
  • serpin family A member 1 (SERPINA1) antibody
  • calumenin (CALU) antibody
  • serpin family A member 1 (Serpina1) antibody
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog (serpina1.S) antibody
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (serpina1) antibody
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 (SPIA5) antibody
  • SH2B adaptor protein 2 (Sh2b2) antibody
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (Serpina1) antibody
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 (SERPINA3) antibody
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 L homeolog (serpina1.L) antibody
  • A1A antibody
  • A1AT antibody
  • AAT antibody
  • alpha-1-PI antibody
  • alpha1AT antibody
  • Aps antibody
  • MGC64429 antibody
  • Pi antibody
  • PI1 antibody
  • PRO2275 antibody
  • serpina1d antibody
  • SERPINA3-5 antibody
  • Spi1 antibody

Protein level used designations for SERPINA1

APF , alpha-1-antiproteinase F , alpha-1-antitrypsin , alpha-1-proteinase inhibitor , alpha-1 protease inhibitor , alpha-1-antiproteinase , serpin A1 , alpha-1 antitrypsin , protease inhibitor 1 , serine (or cysteine) proteinase inhibitor, clade A (alpha-1antiproteinase, antitrypsin), member 1 , alpha-1-antitrypsin null , protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin , serine (or cysteine) proteinase inhibitor, clade A, member 1 , alpha-1-antitrypsin (protease inhibitor) , alpha-1-protease inhibitor , serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 , serine protease inhibitor alpha 1 , serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 , serine (or cysteine) proteinase inhibitor, clade A, member 1d , alpha-1-antiproteinase S , protease inhibitor 1 (anti-elastase, antitrypsin, alpha-1) , serine proteinase inhibitor, clade A, member 1 , alpha 1 antitrypsin , Alpha-1 protease inhibitor , serpin A3-5 , serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 L homeolog

GENE ID SPECIES
100008973 Oryctolagus cuniculus
100171544 Pongo abelii
443388 Ovis aries
100056849 Equus caballus
5265 Homo sapiens
24648 Rattus norvegicus
379963 Xenopus laevis
397688 Sus scrofa
467541 Pan troglodytes
701361 Macaca mulatta
100145012 Xenopus (Silurana) tropicalis
423435 Gallus gallus
100379265 Cavia porcellus
280699 Bos taurus
480422 Canis lupus familiaris
101841330 Mesocricetus auratus
617667 Bos taurus
397792 Xenopus laevis
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