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anti-inflammatory effects of vaspin in 3T3-L1 adipocytes as well as increased insulin signaling by endogenous expression or exogenous treatment, are reported.
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Vaspin can play a specific role in the pathogenesis of metabolic disorders in these subjects and can be a specific indicator substance in BD.
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Elevated levels of vaspin were associated with 1.7 times increased cardiovascular disease risk.
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vaspin rs2236242 polymorphism is not associated with metabolic syndrome in Egyptian women
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vaspin decreased miR-33a levels, which in turn increased ABCA1 expression and cholesteorl efflux.
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High vaspin expression is associated with osteoporosis and arterial stiffness.
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The aims of this study were to evaluate and correlate circulating chemerin, apelin, vaspin, and omentin-1 levels in obese type 2 diabetic Egyptian patients with coronary artery stenosis (CAS), and to assess their usefulness as noninvasive diagnostic biomarkers.
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Serum vaspin concentrations were significantly higher in the type-2 diabetes mellitus (T2DM) group than in the T2DM + macrovascular complications group.
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Serum vaspin level may be a useful marker for the prediction of ovulation induction success in treatment with clomiphene citrate
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vaspin can play a role as a new marker in the diagnosis, severity assessment, and prognosis of subarachnoid hemorrhage
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Suggest vaspin could be involved in the pathophysiology of cirrhosis, but is not a good indicator of its origin or severity and does not impact the thrombotic activity of platelets.
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Vaspin may play an important compensatory role in obesity and insulin resistance in elderly people.
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Studied the effects of vaspin on lipopolysaccharide (LPS)induced acute respiratory distress syndrome (ARDS) in vivo and in vitro, and further explored the molecular basis and potential mechanisms underlying these effects. It was demonstrated that vaspin protects against LPSinduced ARDS through reversing EC barrier dysfunction via the suppression of inflammation, apoptosis and ROS generation in pulmonary ECs.
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Serum vaspin cannot be used as an independent marker for the presence of coronary artery disease in the general population.
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Vaspin is modified at all 3 predicted asparagine glycosylation sites near the reactive center loop. Biochemical data demonstrate that glycosylation does not hinder inhibition of the target protease kallikrein 7. Although binding affinity to heparin is slightly decreased, the protease inhibition reaction is still significantly accelerated in the presence of heparin. Glycosylation did not affect thermal stability.
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Vaspin was associated with a reduced risk of insulin resistance independently of BMI and pubertal stage and the association was influenced by body fat and physical activity in these adolescents.
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Study provides evidence that serum vaspin level could be regarded as the predictor for improvement of fatty liver and metabolic disturbance after laparoscopic vertical banded gastroplasty surgery in patients with severe obesity.
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The minor A allele of vaspin rs2236242 polymorphism plays a protective role against obesity and diabetes among women in Upper Egypt. The serum vaspin concentration was lower in minor protective allele carriers.
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In COPD, the meta-analysis of % predicted FEV1 in cases, the strongest association was shown for a splice variant in a previously unreported region, SERPINA12 (rs140198372, pmeta=5.72x10(-6)).
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Together, these data show that vaspin binds heparin with high affinity (KD = 21 +/- 2 nm) and that binding takes place at a basic patch on top of beta-sheet A and is different from other heparin-binding serpins.
