serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6) ELISA Kits

SERPINA6 encodes an alpha-globulin protein with corticosteroid-binding properties. Additionally we are shipping SERPINA6 Antibodies (166) and SERPINA6 Proteins (36) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
SERPINA6 12401 Q06770
SERPINA6 866 P08185
SERPINA6 299270 P31211
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Top SERPINA6 ELISA Kits at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 20 20 Typical standard curve 96 Tests 13 to 16 Days
$788.33
Details
Rat 6.9 ng/mL 15.6 - 1000 ng/mL SDS-PAGE of Protein Standard from the Kit  (Highly purified E. coli-expressed recombinant rat CBG). WB of Protein Standard: different control antibodies  against Highly purified E. coli-expressed recombinant rat CBG. 96 Tests 12 to 14 Days
$882.44
Details
Mouse 0.2 0.2 Typical standard curve 96 Tests 15 to 18 Days
$788.33
Details
Pig 1.35 5 Typical standard curve 96 Tests 15 to 18 Days
$1,026.67
Details
Cow
  96 Tests 2 to 3 Days
$867.90
Details
Rabbit 1.0 ng/mL 5.0-100 ng/mL   96 Tests 15 to 18 Days
$707.14
Details
Monkey 1.0 ng/mL 5.0-100 ng/mL   96 Tests 15 to 18 Days
$707.14
Details
Human < 0.073 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 11 to 18 Days
$902.56
Details
Rat < 1.25 ng/mL 3.12 ng/mL - 200 ng/mL   96 Tests 11 to 18 Days
$902.56
Details
Mouse < 0.31 ng/mL 0.781 ng/mL - 50 ng/mL   96 Tests 11 to 18 Days
$966.52
Details

Top referenced SERPINA6 ELISA Kits

  1. Rat (Rattus) SERPINA6 ELISA Kit for Sandwich ELISA - ABIN6730988 : Barrientos, Thompson, Kitt, Amat, Hale, Frank, Crysdale, Stamper, Hennessey, Watkins, Spencer, Lowry, Maier: Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia. in Neurobiology of aging 2015 (PubMed)

  2. Human SERPINA6 ELISA Kit for Sandwich ELISA - ABIN6574263 : Charni, Molchadsky, Goldstein, Solomon, Tal, Goldfinger, Yang, Porat, Lozano, Rotter: Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation. in Cell death and differentiation 2016 (PubMed)

More ELISA Kits for SERPINA6 Interaction Partners

Mouse (Murine) serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6) interaction partners

  1. CBG is involved in the gender differences observed in corticosteroids circulating levels and plays a role in the local regulation of corticosteroids availability in organs like lung.

  2. the same gene encodes brain and liver corticosteroid-binding globulin

  3. Data suggest fine control interaction between plasma CBG upregulation and stress-induced corticosterone (CORT) release in mouse model of psychological stress; CBG appears to function in maintaining dynamic equilibrium between CBG-bound/-unbound CORT.

  4. Sequencing analysis showed that Cbg cDNA obtained from the mouse hypothalamus was homologous to Cbg cDNA obtained from the liver.

  5. Cbg-/- mice, unlike controls, remain insensitive to stress applied before memory retrieval. Furthermore, under stress conditions, we observed a blunted surge of corticosterone (CORT) in plasma and no free CORT rise in the hippocampus of Cbg-/-.

  6. study describes functional hyporesponsiveness and aldosterone resistance in distal colon of CBG(-/-) mice; steroid actions require an intrinsic but unknown function of CBG, which allows the sufficient supply of the hormone/s to the target tissue

  7. Critical role of plasma Cbg in providing an adequate endocrine and behavioral response to stress.

  8. These data suggest an active role for CBG in bioavailability, local delivery, and/or cellular signal transduction of glucocorticoids that extends beyond a function as a mere cargo transporter.

Human serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6) interaction partners

  1. N-glycans at other sites also appear to protect CBG from neutrophil elastase or chymotrypsin.

  2. We generated weighted polygenic risk score (PRS) based on 6 genome-wide significant SNPs (rs11621961, rs11629171, rs7161521, rs2749527, rs3762132, rs4900229). salivary cortisol increased in the high PRS group. It remained unchanged in low PRS group. These results were mainly driven by minor alleles of rs7161521 (SERPINA6) and rs4900229 (SERPINA1).

  3. Data suggest that some individuals with adrenal insufficiency due to SERPINA6 mutations present with hypotension or nonspecific symptoms such as fatigue, nausea, or chronic pain, but symptomatology varies widely, even between family members with identical mutations. [REVIEW]

  4. In conclusion, site-specific CBG N-glycosylation regulates the bioavailability of cortisol in inflamed environments by fine-tuning the RCL proteolysis by endogenous and exogenous elastases.

  5. The results suggest reduced CBG cleavage in central obesity, possibly contributing to the characteristic inflammatory phenotype of the central obesity and metabolic syndrome.

  6. Corticosteroid-binding globulin cleavage may be pathogen-dependent in bloodstream infection

  7. Data indicate there was no significant circadian variation in serum cortisol-binding globulin (CBG) concentration in any of the 4 groups.

  8. Human cardiomyocytes express mineralocorticoid receptors, but are mostly free of nuclear glucocorticoid receptors. CBG is expressed in myocardium and in Purkinje fibers. CBG in heart is colocalized with mineralocorticoid receptor.

  9. SERPINA6-rs1998056 regulated by FOXA/ERalpha might be associated with female HCC risk

  10. genetic variation in the SERPINA6 gene may be associated with altered CBG levels during adolescence.

  11. the results suggest that DEX repression of Corticosteroid-binding globulin involves tethering of the glucocorticoid receptor to C/EBPb.

  12. 8 naturally occurring CBG mutants with abnormalities in cortisol-binding affinity, cortisol-binding capacity, production/secretion, sensitivity to proteolytic cleavage of the reactive center loop, or recognition by monoclonal antibodies used for ELISAs were identified

  13. The study investigate the half-life of intact and elastase cleaved CBG in the rabbit. The half-lives of intact and cleaved human CBG are 10 h and identical.

  14. CBG is coexpressed with hypothalamic neuropeptides.CBG may be involved in control of systemic and central stress response.

  15. Exome chip and 1000 Genomes imputation analysis of this locus in the CROATIA-Korcula cohort identified missense mutations in SERPINA6 and SERPINA1 that did not account for the effects of common variants

  16. Atomic interactions observed between progesterone and CBG explain the lower affinity of progesterone in comparison to corticosteroids.

  17. investigation of physicochemical, electronic, and structural requirements for selective and effective binding of steroids (many are endogenous steroid metabolites) to CBG and SHBG active/ligand-binding sites

  18. The influence of glucocorticoid receptor and corticosteroid-binding globulin gene polymorphisms in obesity and/or cortisol action in prepubertal obese children.

  19. three polymorphisms, -26 C/G, -54 C/T, and -144 G/C located close to the putative hepatic nuclear factor (HNF) 1 binding elements, altered the transactivation effect of HNF1beta

  20. genetic association studies in Chinese populations: Data suggest that SERPINA6 with SNP (A51V) is poorly produced/secreted; plasma corticosteroid-binding globulin levels in heterozygous subjects for this variant are 50% lower than in normal subjects.

Pig (Porcine) serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 (SERPINA6) interaction partners

  1. non-synonymous polymorphisms of SERPINA6, particularly SNPs c.919G>A and c.44G>T/c.622C>T, are associated with cortisol level, HPA axis activity, and carcass and meat quality traits

  2. The putative causal amino acid substitution p.Gly307Arg (SNP c.919G>A) associated with meat quality (drip loss) was only detected in European domestic pig breeds, suggesting a very recent mutation that appeared after domestication in Europe.

  3. Cbg gene is a key regulator of cortisol levels and obesity susceptibility.

  4. Negative relationship exists between plasma cortisol and CBG under conditions of acute stress.

SERPINA6 Antigen Profile

Antigen Summary

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events.

Gene names and symbols associated with SERPINA6

  • serpin family A member 6 (SERPINA6) antibody
  • serpin family A member 6 L homeolog (serpina6.L) antibody
  • corticosteroid-binding globulin (LOC490838) antibody
  • serine (or cysteine) peptidase inhibitor, clade A, member 6 (Serpina6) antibody
  • serpin family A member 6 (Serpina6) antibody
  • AI265318 antibody
  • AV104445 antibody
  • CBG antibody
  • ep45-A antibody
  • SERPINA6 antibody

Protein level used designations for SERPINA6

CBG , corticosteroid-binding globulin , serpin A6 , transcortin , serine protease inhibitor A6 , estrogen-regulated protein EP45 , serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 , corticosteroid binding globulin , serine (or cysteine) proteinase inhibitor, clade A, member 6 , serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 , serine (or cysteine) peptidase inhibitor, clade A, member 6 , serpin peptidase inhibitor, clade A, member 6

GENE ID SPECIES
100172888 Pongo abelii
373636 Xenopus laevis
453131 Pan troglodytes
490838 Canis lupus familiaris
701121 Macaca mulatta
100356417 Oryctolagus cuniculus
12401 Mus musculus
866 Homo sapiens
299270 Rattus norvegicus
396736 Sus scrofa
101118224 Ovis aries
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