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SGK2 encodes a serine/threonine protein kinase.
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Human Polyclonal SGK2 Primary Antibody for IHC (p), WB - ABIN1882131
Friedrich, Feng, Cohen, Risler, Vandewalle, Bröer, Wang, Pearce, Lang: The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC. in Pflügers Archiv : European journal of physiology 2003
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Loss of the paternally derived allele of the imprinted SGK2 gene is associated with Shwachman-Diamond syndrome.
These findings suggest that SGK2 promotes hepatocellular carcinoma progression and mediates glycogen synthase kinase 3 beta/beta-catenin (show CTNNB1 Antibodies) signaling in hepatocellular carcinoma cells.
SGK2 stimulated hOAT4 (show SLC22A9 Antibodies) transport activity by abrogating the inhibitory effect of Nedd4-2 (show NEDD4L Antibodies) on the transporter.
Activation of hepatocyte pregnane X receptor (show NR1I2 Antibodies) is mediated through serum- and glucocorticoid-regulated kinase (SGK)2.
Glucocorticoid inducible kinase isoforms SGK1 (show SGK1 Antibodies)-3 are novel potent stimulators of Slc6a19 (show SLC6A19 Antibodies) and may thus participate in the regulation of neutral amino acid transport in vivo.
Powerful stimulating effect of all three isoforms of SGK (show SGK1 Antibodies) on K(+) channels. Those effects may participate in regulation of epithelial transport, cell proliferation, and neuromuscular excitability.
All three members of the SGK (show SGK1 Antibodies) family of kinases SGK1 (show SGK1 Antibodies)-3 and protein kinase B (show AKT1 Antibodies) stimulate the slowly activating K(+) channel (show KCNC4 Antibodies) KCNE1 (show KCNE1 Antibodies)/KCNQ1 (show KCNQ1 Antibodies). The kinases may thus participate in the regulation of KCNE1 (show KCNE1 Antibodies)-dependent transport and excitability.
Co-expression of SGK1 (show SGK1 Antibodies), but not of SGK2 or SGK3 (show SGK3 Antibodies), increased Kv 4.3/KChIP2b (show KCNIP2 Antibodies) channel currents.
VRK1 (show VRK1 Antibodies) self-represses its activity to phosphorylate PXR (show NR1I2 Antibodies) through cyclin-dependent kinase 2 (CDK2 (show CDK2 Antibodies)) in high glucose conditions, resulting in the repression of the PCK1 (show PCK1 Antibodies) gene. This PXR (show NR1I2 Antibodies) phosphorylation was also observed in fasting mouse livers. Thus, the VRK1 (show VRK1 Antibodies)-CDK2 (show CDK2 Antibodies)-PXR (show NR1I2 Antibodies)-PP2Calpha (show PPM1A Antibodies)-SGK2 pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.
the nucleotide substitution in the Sgkl gene is the causative mutation for defective hair growth in the ypc mutant mouse and the signaling pathway involving SGKL plays an essential role in mammalian hair development
This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants.
serine/threonine-protein kinase Sgk2
, serum/glucocorticoid-regulated kinase 2
, serum/glucocorticoid regulated kinase family, member 3
, serum/glucocorticoid regulated kinase 2
, serine/threonine-protein kinase Sgk3