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Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. Additionally we are shipping THG1L Antibodies (24) and many more products for this protein.
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Study proposes that homozygosity for the p.Val55Ala mutation in tRNA-histidine guanylyltransferase 1 like (THG1L) is the cause of the abnormal mitochondrial network in the patient fibroblasts, likely by interfering with THG1L activity towards MFN2 (show MFN2 Proteins).
The high-resolution crystal structure of human Thg1 reveals remarkable structural similarity between canonical DNA/RNA polymerases and eukaryotic Thg1.
IHG-1 (show FOXC1 Proteins) is a novel regulator of both mitochondrial dynamics and bioenergetic function and contributes to cell survival following oxidant stress. Increased IHG-1 (show FOXC1 Proteins) expression may contribute to pathogenesis of diabetic kidney disease.
IHG-1 increases mitochondrial biogenesis by promoting PGC-1alpha-dependent processes, potentially contributing to the pathogenesis of renal fibrosis
The catalytic domain of Thg1 shares both a common architecture and a two-metal ion-dependent mechanism with canonical 5'-3' DNA polymerases.
ICF45 is a highly conserved novel protein, which is expressed in a cell cycle-dependent manner and seemed to be involved in cell cycle progression and cell proliferation
induced in high glucose-1 (IHG-1 (show FOXC1 Proteins))which increases in diabetic nephropathy, may enhance the actions of TGF-beta1 (show TGFB1 Proteins) and contribute to the development of tubulointerstitial fibrosis
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (By similarity).
probable tRNA(His) guanylyltransferase
, tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
, interphase cytoplasmic foci protein 45
, probable tRNA(His) guanylyltransferase-like
, induced by high glucose-1
, nterphase cyctoplasmic foci protein 45