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TNK2 encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. Additionally we are shipping tyrosine Kinase, Non-Receptor, 2 Antibodies (206) and tyrosine Kinase, Non-Receptor, 2 Kits (25) and many more products for this protein.
Showing 9 out of 11 products:
we demonstrate that amplification of ACK1 promotes gastric tumorigenesis by inducing an ECD (show SHFM1 Proteins)-dependent ubiquitination degradation of p53 (show TP53 Proteins)
These findings suggest that ACK adopts a dock and coalesce binding mechanism with Cdc42. In contrast to other CRIB-family effectors and indeed other intrinsically disordered proteins, hydrophobic residues likely drive Cdc42-ACK binding.
miR (show MLXIP Proteins)-24 represses metastasis of human osteosarcoma cells by targeting Ack1 v (show AKT1 Proteins)ia AK (show MMP2 Proteins)T-MMP (show MMP9 Proteins)2-MMP9 pathway.
findings identify ACK1 as a novel SLP-76 (show LCP2 Proteins)-associated protein-tyrosine kinase (show EPHA8 Proteins) that modulates early activation events in T cells.
ACK1 protein is increased extensively in colitis and colorectal dysplasia. ACK1 overexpression may play a role in colorectal inflammation and neoplasms.
Ack1 overexpression promotes metastasis in hepatocellular carcinoma.
Results found that the expression of ACK1 was significantly up-regulated in non-small-cell lung cancer (NSCLC) samples and demonstrate that ACK1 played an oncogenic role in the progression of NSCLC.
Authors identified tyrosine kinase (show TXK Proteins) nonreceptor 2 (TNK2) point mutations that exhibited oncogenic capacity.
that the cdc42 (show CDC42 Proteins)-activated, nonreceptor tyrosine kinase (show TXK Proteins), Ack1, is a DAT (show SLC6A3 Proteins) endocytic brake that stabilizes DAT (show SLC6A3 Proteins) at the plasma membrane.
TNK2 (and TNR (show TNR Proteins)) harbored rare, genetic variants in individuals with familial Parkinson's Disease.
miR (show MLXIP Proteins)-24 represses metastasis of osteosarcoma cells by targeting Ack1 via AKT (show AKT1 Proteins)-MMP2 (show MMP2 Proteins)-MMP9 (show MMP9 Proteins) pathway.
findings identify ACK1 as a novel SLP-76 (show LCP2 Proteins)-associated protein-tyrosine kinase (show YES1 Proteins) that modulates early activation events in T cells.
that the cdc42 (show CDC42 Proteins)-activated, nonreceptor tyrosine kinase (show TYRO3 Proteins), Ack1, is a DAT (show SLC6A3 Proteins) endocytic brake that stabilizes DAT (show SLC6A3 Proteins) at the plasma membrane.
ACK1 directly binds and phosphorylates the Arp2 (show AICDA Proteins)/3 regulatory protein (show TGFB1 Proteins) cortactin (show CTTN Proteins), potentially providing a direct link to Arp2 (show AICDA Proteins)/3-based actin dynamics during EGFR (show EGFR Proteins) degradation.
Ack1-mediated androgen receptor (show AR Proteins) phosphorylation modulates radiation resistance in castration-resistant prostate cancer
Ack1 mediated AKT/PKB (show AKT1 Proteins) tyrosine 176 phosphorylation regulates its activation
Ack1/Pyk1 tyrosine kinase (show TYRO3 Proteins) may be involved both in adult synaptic function and plasticity and in brain development.
Ack1 is up-regulated during development and is expressed in proliferative areas and in migratory pathways in the developing brain.
These experiments suggest a functional role for Ack as an early transducer of multiple extracellular stimuli.
These studies suggest that ACK1 senses signal of epidermal growth factor (EGF (show EGF Proteins)) and regulates ligand-induced degradation of EGFR (show EGFR Proteins).
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
activated CDC42 kinase 1
, activated Cdc42-associated kinase 1
, activated p21cdc42Hs kinase
, tyrosine kinase non-receptor protein 2
, Cdc42 GTPase-inhibiting protein
, P21cdc42Hs kinase
, non-receptor protein tyrosine kinase ACK
, activated CDC42 kinase 2