μ-conotoxin CnIIIC

Catalog No. ABIN2566216

Product Details

Application: Blocking Reagent (BR)

Sequence: AA sequence: Pyr-Gly-Cys3-Cys4-Asn-Gly-Pro-Lys-Gly-Cys10 -Ser-Ser-Lys-Trp-Cys15-Arg-Asp-His-Ala-Arg- Cys21-Cys22-NH2 Disulfide bonds: Cys3-Cys15, Cys4-Cys21 and Cys10-Cys22

Characteristics: μ-conotoxin CnIIIC is a selective blocker of Nav1.4 channels

Application Details

Restrictions: For Research Use only

Handling

Storage: -20 °C

Target Details

Background: μ-conotoxin CnIIIC has been isolated from the venom of the marine cone snail Conus consors. μ-conotoxin CnIIIC exhibits a myorelaxing effect through specific blockade of the skeletal muscle Nav1.4 channels (IC50 = 1.4 nM). μ-conotoxin CnIIIC also blocks Nav1.2 channels (1 μM) and mildly Nav1.7. In contrast, Nav1.5 and Nav1.8 are insensitive to the action of the toxin. μ-conotoxin CnIIIC also blocks the α3β2 nicotinic acetylcholine receptor (IC50 = 450 nM) and to lesser extents the α7 and α4β2 subtypes. μ-conotoxin CnIIIC completely inhibits twitch tension in isolated mouse hemidiaphragms (IC50 = 150 nM).

Molecular Weight: 2375.8 kDa