TRAIL-R1 to -R4 (human) Flow Cytometry Pack

Catalog No. ABIN2745408

Quick Overview for TRAIL-R1 to -R4 (human) Flow Cytometry Pack (ABIN2745408)

Target: TRAIL-R1-R4

Application: Flow Cytometry (FACS)

Product Details

Cross-Reactivity: Human

Components: 100μg each of: anti-TRAIL-R1, anti-TRAIL-R2, anti-TRAIL-R3, anti-TRAIL-R4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Expiry Date: 6 months

Target Details

Target: TRAIL-R1-R4

Background: TRAIL-R1, -R2, -R3 and -R4 are receptors for the cytotoxic ligand TRAIL. When signaling through TRAIL-R1 and -R2, the adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. They promote the activation of NF-kappaB. TRAIL-R3 lacks a cytoplasmic death domain, and TRAIL-R4 contains a truncated death domain, and hence are not capable of inducing apoptosis. They protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.