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kinin B1 receptor (B1R) gene ortholog(BDKRB1)was confirmed; putative Zn2+-binding motif HEXXH is not present (replaced by HDAWP); receptor binds [3H]Lys (show LYZ Proteins)-des (show DES Proteins)-Arg9-bradykinin (K(d) 0.36 nM) and exhibits a pharmacological profile like human B(1)R
The findings revealed that serum B1R levels may provide prognostic information and currently act as potential indicators for progression in atherosclerosis.
Data show that mRNA and protein of bradykinin type 2 receptors, but not bradykinin type 1 receptors, were abundant in cultured c-Kit+ progenitor cells.
BKR1 and BKR2 (show BDKRB2 Proteins) gene expression on peripheral monocytes is upregulated in essential hypertension
B1R agonist acts as a functional stimulus for the secretion of KLK1 (show KLK1 Proteins) and KLK6 (show KLK1 Proteins), an event relevant for kinin production and cell invasion, respectively
Bradykinin B1 receptor signaling depends on receptor endocytosis.
APJ (show APLNR Proteins) and B1R can form heterodimers in transfected HEK293 cells and activations of APJ (show APLNR Proteins) and B1R could up-regulate eNOS (show NOS3 Proteins) phosphorylation
investigated if expression of B1 and B2 kinin receptors can be affected by IL-4 (show IL4 Proteins) and IL-13 (show IL13 Proteins); data show, for the first time, that IL-4 (show IL4 Proteins) and IL-13 (show IL13 Proteins) decrease kinin receptors in a STAT6 (show STAT6 Proteins)-dependent mechanism
A novel B1R splice variant and promoter regulatory elements determine tissue-specific B1R expression.
the relevance of kinin B1 and B2 receptors in bladder cancer, was investigated.
CPM (show CPM Proteins) binding to extracellular loop 2 of the B1R results in positive allosteric modulation of B1R signaling, and disruption of this interaction could provide a novel therapeutic approach to reduce pathological B1R signaling.
B1 receptors are coupled to COX2 (show PTGS2 Proteins) in causing endothelium-independent contractions in endotoxin-treated pig coronary arteries
study revealed that TRPA1 positively modulates the mechanical hyperalgesia induced by B1 receptor activation in the spinal cord and that the classical GPCR downstream molecules
Host kinin B1 receptor plays a protective role against melanoma progression.
Studied nitric oxide (NO) release, L-arginine (show GATM Proteins) (L-Arg) uptake and the expression of the cationic amino acid transporter (CAT) -1 (show SLC7A1 Proteins) in endothelial cells obtained from B1 receptor knockout (B1-/-) and wild type (WT) mice.
Kinin B1R contributes to acute gouty attacks, including the ones facilitated by ACEi.
Kinin B1 receptor deletion affects bone healing in type 1 diabetic mice with femoral defects.
Kinin B1 receptor deficiency or antagonism diminishes apoptosis caused by cisplatin.
Bradykinin plays an important role in the pathogenesis of anti-collagen antibody-induced arthritis (CAIA). Bradykinin receptor beta 1, whose expression is induced in inflamed joint tissue, is important in the development of CAIA.
The kinin B1 receptor plays a significant role in the regulation of skeletal muscle proteolysis in the levator ani (show ANLN Proteins) muscle atrophy model.
Genetic deletion of kinin B1R attenuates cognitive deficits and blocks mRNA expression of IL-17 (show IL17A Proteins) and IFN-gamma (show IFNG Proteins) in mice subjected to autoimmune encephalitis.
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene.
B1 bradykinin receptor
, B1 like bradykinin receptor
, bradykinin receptor B2
, bradykinin receptor B1
, b1 bradykinin receptor-like
, BK-1 receptor
, bradykinin B1 receptor
, bradykinin receptor 1
, bradykinin receptor, beta 1
, kinin B1 receptor
, G-protein coupled receptor
, kinin B1