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Promoter of ITIH4 major acute phase protein has been isolated, cloned, and proven functional by response to an inflammatory stimulus (interleukin-6 (show IL6 Proteins)) in human Hep3B cells. (inter-alpha-trypsin heavy chain 4; ITIH4 (show ITIH4 Proteins))
Three loci showed robust, replicating association with circulating FXI (show F11 Proteins) levels: KNG1 (rs710446, P-value = 2.07 x 10-302), F11 (show F11 Proteins) (rs4253417, P-value = 2.86 x 10-193), and a novel association in GCKR (show GCKR Proteins) (rs780094, P-value = 3.56 x10-09), here for the first time implicated in FXI (show F11 Proteins) regulation. The two first SNPs (rs710446 and rs4253417) also associated with partial thromboplastin (show F3 Proteins) time
findings show that the KNG1 locus plays a central role as a genetic determinant of the entire coagulation pathway and thrombus/clot (show TXNDC17 Proteins) formation
Urinary KNG1 and RBP4 clearly respond to AKI. Additionally, RBP4 could predict recovery by monitoring this protein levels over time after AKI, as RBP4 reflects patient's normalization earlier than sCr values do.
KNG1 rs710446/ rs2304456 SNPs are not related to the incidence of Alzheimer's disease in a Hunan Han Chinese population.
Low urine KNG1 expression is associated with clear cell renal cell carcinoma (show MOK Proteins).
The results of this study supported the association of the epistatic interactions of ALOX5AP (show ALOX5AP Proteins), THBD (show THBD Proteins), and KNG1 and present novel evidence for the main effect of KNG1 gene on IS susceptibility.
Bradykinin stimulates pro-contractile signalling mechanisms in human myometrial cells and arrestin (show SAG Proteins) proteins play key roles in their regulation.
2 genetic loci (kininogen 1 and kallikrein (show KLK4 Proteins) B) influencing key components of the RAAS, consistent with the close interrelation between the kallikrein (show KLK4 Proteins)-kinin system and the RAAS.
Measuring plasma levels of cleaved HK may be a sensitive mean of assessing disease severity in HAE-C1-INH (show SERPING1 Proteins) patients.
The antimicrobial protein kininogen evolved adaptively in mammals and human populations.
uPAR (show PLAUR Proteins) mediates efferocytosis through high molecular weight kininogen interaction with phosphatidylserine on apoptotic cells
mice deficient in KNG showed less severe blood-brain barrier damage and edema formation, and the local inflammatory response was reduced compared with controls.
Domain 5 of kininogen was identified as an anti-adhesive component with a potent anti-inflammatory action in a peritonitis mouse model.
His-Gly-Lys (show LYZ Proteins) motif and lysine residue (Lys487) play essential roles in inhibition of cell adhesion and invasion in vitro and in prevention of metastasis of cancer cells in vivo
mKng1 is responsible for production of plasma kininogen
Bradykinin, together with its precursor and tissue kallikrein (show KLK1 Proteins), is continuously released into the vasculature of the isolated, perfused, lactating bovine udder.
Bradykini stimulates endothelial cell fatty acid oxidation by calmodulin-dependent kinase kinase -dependent activation of AMP-activated protein kinase (AMPK (show PRKAA2 Proteins))
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
, kininogen 1
, ITI heavy chain H4
, inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
, inter-alpha-inhibitor heavy chain 4
, inter-alpha-trypsin inhibitor family heavy chain-related protein
, inter-alpha-trypsin inhibitor heavy chain H4
, major acute phase protein
, alpha-2-thiol proteinase inhibitor
, fitzgerald factor
, high molecular weight kininogen
, williams-Fitzgerald-Flaujeac factor
, kininogen I
, kininogen II
, thiol proteinase inhibitor
, K-kininogen, differential splicing leads to HMW Kngk
, LMW T-kininogen I
, T-kininogen 1
, T-kininogen I
, kininogen 1, variant 1
, low molecular weight kininogen
, T-kininogen 2
, T-kininogen II
, low molecular weight (LMW) T-kininogen II
, major acute phase protein (alpha-1-MAP)