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GARP (show CNGB1 Proteins) is a surface molecule of regulatory T cells with roles in the regulatory function and TGF-beta (show TGFB1 Proteins) releasing [review]
Data show that the Treg activation marker GARP (glycoprotein A repetitions predominant) is expressed on primary melanoma.
High GARP (show CNGB1 Proteins) expression is associated with pancreatic cancer and liver metastases from colorectal cancer.
study showed that stimulated, human B lymphocytes produce active TGF-beta1 from surface GARP/latent TGF-beta1 complexes with isotype switching to IgA production.
GARP (show CNGB1 Proteins) plays an important role in the pathogenesis of atopic dermatitis.
CD4 (show CD4 Proteins)(+) CD25 (show IL2RA Proteins)(+) GARP (show CNGB1 Proteins)(+) Treg cells are defective in dilated cardiomyopathy patients and GARP (show CNGB1 Proteins) seems to be a better molecular definition of the regulatory phenotype.
these results define the oncogenic effects of the GARP (show CNGB1 Proteins)-TGFbeta (show TGFB1 Proteins) axis in the tumor microenvironment
LRRC32 expression is significantly upregulated in human masticatory mucosa during wound healing
GARP (show CNGB1 Proteins) deficiency leads to accumulation of sphingolipid synthesis intermediates, changes in sterol distribution, and lysosomal dysfunction.
since GARP (show CNGB1 Proteins) functions as a transporter of transforming growth factor beta (TGFbeta (show TGFB1 Proteins)), a cytokine with broad pleiotropic traits, GARP (show CNGB1 Proteins) transcriptional attenuation by alternative promoters might provide a mechanism regulating peripheral TGFb (show TGFB1 Proteins)
Data (including data from studies using knockout mice) suggest that Garp/Lrrc32 is involved in up-regulation of Tgfb3 (show TGFB3 Proteins) and is essential for normal embryogenesis of palate; knockout of Garp causes postnatal lethality, cleft palate, and decreased apoptosis and Smad2 (show SMAD2 Proteins) phosphorylation in medial edge epithelial cells of palatal shelf of embryos. (Tgfb3 (show TGFB3 Proteins) = transforming growth factor beta 3 (show TGFB3 Proteins); Smad2 (show SMAD2 Proteins) = MAD homolog protein 2)
These results demonstrate the unexpected presence of GARP on Hepatic stellate cells and its significance in regard to the ability of Hepatic stellate cells to activate latent TGF-beta1 (show TGFB1 Proteins) and thereby inhibit T cells.
GARP expression on MSCs contributed to their ability to inhibit T-cell responses in vitro.
We conclude that a missense mutation in VPS54, an essential component of the Golgi-associated retrograde protein complex, not only prevents the formation of an acrosome but also initiates a cascade of metabolic abnormalities and a stress reaction.
These findings suggest a role for GARP in natural and induced Treg development through activation of bound latent TGF-beta (show TGFB1 Proteins) and signaling, which negatively regulates GARP expression on Tregs.
GARP is a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 (show FOXP3 Proteins) expression
This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies.
leucine rich repeat containing 32
, leucine-rich repeat-containing protein 32
, leucine-rich repeat-containing protein 32-like
, glycoprotein A repetitions predominant