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CISD2 haploinsufficiency disrupts calcium homeostasis, causing ER stress and subsequent nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
CISD2 was increased in glioma samples and was associated with poor prognosis and aggressive tumor behavior. The miR449a/CISD2/beclin1mediated autophagy regulatory network contributed to the proliferation of glioma cells
CISD2 is down-regulated in gastric cancer, and its effects on the inhibition of cellular proliferation, metastatic ability, and increased chemotherapy sensitivity are mediated by antagonism to 5-FU-induced autophagy through the AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) pathway.
The c.103 + 1G > A mutation resulted in the loss of functional CISD2 protein in the two Italian Wolfram syndrome type 2 patients.
CISD2 was up-regulated in laryngeal squamous cell carcinoma
CISD2 could be an independent prognostic factor for PC and suggested that the CISD2/Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway contributed to the proliferation of PC and EMT (show ITK Proteins)
the patient that we describe in this report with the c.215A > G missense CISD2 variant had the classical features of Wolfram syndrome type 1. The c.215A > G (p.Asn72Ser) variant does not induce CISD2 RNA mis (show AMH Proteins)-splicing or a reduction in CISD2 protein levels. Thus, we report a novel missense homozygous CISD2 mutation in a patient with clinical features that differ from previously reported Wolfram syndrome 2 case reports.
CISD2 exerts anti-apoptotic and anti-inflammatory effects in neural cells; and (2) curcumin can attenuate the downregulation of CISD2 in SCI and LPS (show IRF6 Proteins)-treated astrocytes.
CISD2 protein may serve as a candidate prognostic marker and a novel therapeutic target for hepatocellular carcinoma (HCC (show FAM126A Proteins)) and play an important role in promoting proliferation and enhanced progression of HCC (show FAM126A Proteins).
The findings suggested that CISD2 haplotype-tagging single nucleotide polymorphisms are not associated with Alzheimer's disease risk.
These results suggest that the thermosensitive FA-loaded hydrogel could rescue Cisd2(-/-) CM from oxidative stress-induced (show SQSTM1 Proteins) damage and may have potential applications in the future treatment of CVD.
NAF-1 (show TNIP1 Proteins), a BCL-2 (show BCL2 Proteins)-associated autophagy regulator, is required for homeostatic maintenance of skeletal muscle
Cisd2 deficiency impairs the activation of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling
Results suggest that that Cisd2 plays an important role in intracellular Ca21 homeostasis, which is required for the differentiation and functioning of adipocytes as well as the regulation of glucose homeostasis in mice.
Miner1 is a redox protein that resides in the ER and that regulates the UPR and mitochondrial function.
CISD2 has a role in lifespan control and disease [review]
Cisd2 deficiency in mice causes mitochondrial breakdown and dysfunction accompanied by autophagic cell death, and these precede nerve and muscle degeneration; together, they lead to a panel of phenotypic features suggestive of premature aging
The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2.
CDGSH iron-sulfur domain-containing protein 2
, endoplasmic reticulum intermembrane small protein
, mitoNEET related 1
, mitoNEET-related 1 protein
, nutrient-deprivation autophagy factor-1
, zinc finger, CDGSH-type domain 2
, CDGSH iron sulfur domain-containing protein 2
, nervous system over-expressed protein 70
, nervous system overexpressed protein 70
, CDGSH iron-sulfur domain-containing protein 2A
, CDGSH iron sulfur domain-containing protein 2A
, CDGSH iron sulfur domain-containing protein 2-A
, CDGSH iron sulfur domain-containing protein 2-B
, CDGSH iron sulfur domain-containing protein 2B
, CDGSH iron-sulfur domain-containing protein 2B
, CDGSH iron sulfur domain 2