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Human Monoclonal KLRK1 Primary Antibody for CyTOF, FACS - ABIN4900832
Windheim, Southcombe, Kremmer, Chaplin, Urlaub, Falk, Claus, Mihm, Braithwaite, Dennehy, Renz, Sester, Watzl, Burgert: A unique secreted adenovirus E3 protein binds to the leukocyte common antigen CD45 and modulates leukocyte functions. in Proceedings of the National Academy of Sciences of the United States of America 2013
Show all 43 Pubmed References
Human Monoclonal KLRK1 Primary Antibody for FACS - ABIN4898795
Lee, Kang, Yoon, Jin, Song, Her, Kang, Hwang, Kang, Joo, Nam: Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain. in BMC cancer 2015
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Human Monoclonal KLRK1 Primary Antibody for FACS, Func - ABIN1027685
Valencia, Hernández-López, Martínez, Hidalgo, Zapata, Vicente, Varas, Sacedón: Transient beta-catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors. in Journal of leukocyte biology 2010
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Human Monoclonal KLRK1 Primary Antibody for FACS, Func - ABIN1027688
Ebert, Meuter, Moser: Homing and function of human skin gammadelta T cells and NK cells: relevance for tumor surveillance. in Journal of immunology (Baltimore, Md. : 1950) 2006
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Human Monoclonal KLRK1 Primary Antibody for FACS, Func - ABIN1027687
Hasenkamp, Borgerding, Uhrberg, Falk, Chapuy, Wulf, Jung, Trümper, Glass: Self-tolerance of human natural killer cells lacking self-HLA-specific inhibitory receptors. in Scandinavian journal of immunology 2008
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Human Monoclonal KLRK1 Primary Antibody for FACS, Func - ABIN1027686
Sangiolo, Martinuzzi, Todorovic, Vitaggio, Vallario, Jordaney, Carnevale-Schianca, Capaldi, Geuna, Casorzo, Nash, Aglietta, Cignetti: Alloreactivity and anti-tumor activity segregate within two distinct subsets of cytokine-induced killer (CIK) cells: implications for their infusion across major HLA barriers. in International immunology 2008
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Human Monoclonal KLRK1 Primary Antibody for Func, IHC (f) - ABIN2749125
Wu, Groh, Spies: T cell antigen receptor engagement and specificity in the recognition of stress-inducible MHC class I-related chains by human epithelial gamma delta T cells. in Journal of immunology (Baltimore, Md. : 1950) 2002
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Human Monoclonal KLRK1 Primary Antibody for FACS - ABIN4898789
Vossen, Matmati, Hertoghs, Baars, Gent, Leclercq, Hamann, Kuijpers, van Lier: CD27 defines phenotypically and functionally different human NK cell subsets. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Human Monoclonal KLRK1 Primary Antibody for FACS - ABIN1177305
Bauer, Groh, Wu, Steinle, Phillips, Lanier, Spies: Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. in Science (New York, N.Y.) 1999
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Human Polyclonal KLRK1 Primary Antibody for IF (p), IHC (p) - ABIN730078
Mozer-Lisewska, Mania, Kowala-Piaskowska, Kluk, Samara, Pauli, ?eromski: Detection and significance of cytotoxic cell subsets in biopsies of HCV-infected human livers. in Archivum immunologiae et therapiae experimentalis 2014
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By an enhanced local cytotoxic response through the NKG2D receptor-ligand pathway.
in this review, authors provide an overview of the impact of NKG2D stimulation during hematopoietic development and during acute and chronic stimulation in the periphery on immune cell responsiveness
NK cells are important cytotoxic cells in the immune system, and the activated NKG2D receptor on the NK cell surface can bind to NKG2D ligands expressed in tumor cells, enabling NK cells to activate and kill tumor cells. (Review)
CD56 + T cells expressing NKG2D, especially in the NKG2D(Hi) population may be involved in pathogenesis and severity of T2D via IL-17.
Authors found NK cell cytotoxicity to CRPC cells decreases when tumor cells are treated with adipocyte CM associated with PD-L1 and NKG2D ligand level alterations.
Exogenous HBsAg stimulated NKG2D expression on NK cells from CHB patients which inhibit HCV replication, suggesting that HBsAg may facilitate the clearance of HCV in patients with HBV/HCV co-infection.
this paper shows that the decreased expression of activating receptor NKG2D on peripheral blood NK cells is positively associated with gastric cancer progression
Finding indicate that HDAC3 and STAT3 signaling cooperate in the regulation of NKG2D expression in natural killer cells.
Low NKG2D expression on NKT cells is associated with Nasopharyngeal Carcinoma.
Sole engagement of NKG2D, 2B4 or DNAM-1 is insufficient for NF-kappaB activation.
Study demonstrates that NKG2D regulates immune inflammation and anti-viral response partly through activation of natural killer cells during HBV infection.
Results suggest that NKG2D+CD4+ T cells are involved in the pathogenesis of systemic lupus erythematosus by killing Treg cells in a NKG2D-NKG2DL-dependent manner.
Our results demonstrate NKG2D-4-1BB-CD3z CAR-redirected memory T cells target NKG2DL-expressing osteosarcoma cells in vivo and in vitro and could be a promising immunotherapeutic approach for patients with osteosarcoma
The NKG2D rs1049174 variant occurs within a targeting site for miR-1245, a negative regulator of NKG2D expression. Compared with the higher cytotoxicity allele HNK, the LNK allele was more efficiently targeted by miR-1245 and thus determined lower NKG2D expression in NK cells with the LNK genotype.
Report altered expression of miR-27a*/NKG2D/ULBP2 in peripheral blood mononuclear cells and natural killer cells of pediatric systemic lupus erythematosus patients.
Strategies to block MICA-NKG2D interactions resulted in reductions in IFNgamma production. Depletion of monocytes in vivo resulted in decreased IFNgamma production by murine NK cells upon exposure to Ab-coated tumor cells
this study shows that aberrant NKG2D expression with IL-17 production of CD4+ T subsets in patients with type 2 diabetes
CD45 is a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells
data demonstrate the robust antitumor activity of these NKG2D ligand-binding bispecific proteins and support their further development for clinical use.
our results define cancer cell NKG2D as an important regulator of tumor initiation in ovarian cancer and presumably other malignancies and thus challenge current efforts in immunotherapy aimed at enhancing NKG2D function
NKG2D is an essential receptor required for the activation of iNKT cells in Con A-induced hepatitis
Data show that indoleamine 2,3 dioxygenase-1 (IDO1)/ miR-18a/ killer cell lectin-like receptor subfamily K (NKG2D/NKG2DL) regulatory axis in the regulation of NK cell function.
we show that NKG2D sets activation threshold for NCR1 early in NK cell development, which determines the sensitivity of NK cells to cellular targets expressing NCR1 ligands.
Pathogen-induced AI memory cells can be distinguished in mice from naturally generated IN memory cells by surface expression of NKG2D.
Clearance of lung cancer is facilitated by up-regulation of NKG2D, NKp46, and other activating receptors upon exposure to environmental MHCI.
Study demonstrated a novel outcome for Nkg2d in its capacity to promote rather than delay tumor progression in the context of liver carcinogenesis.
Interaction between NKG2D and endogenous RAE-1delta desensitizes NK cells and impairs antitumor NK responses and tumor rejection.
Loss of NKG2D expression accelerates rejection of cardiac allografts.
The adoptive transfer of NK1.1(-) CD4(+) NKG2D(+) cells suppressed DSS-induced colitis largely dependent on TGF-beta. Thus, NK1.1(-) CD4(+) NKG2D(+) cells exhibited immune regulatory functions, and this T cell subset could be developed to suppress inflammation in clinics.
IL-15 mediated up-regulation of the activation receptor NKG2D and its adaptor DAP10 in B-1a cells indicating their essential coupling with IL-15 receptor signaling pathway.
NKG2DL low expressing cancer cells formed palpable allogeneic tumors in mice within a week after the inoculation, while NKG2DL high expressing cancer cells failed to proliferate and were prevented from forming tumors.
NKG2D is upregulated, and ROS and caspase-3 are inhibited by Strongylocentrotus nudus egg polysaccharide-enhanced antitumor 5-FU in mice
High NKG2D expression is associated with the Development of Bronchiolitis Obliterans.
tumoral NKG2D stimulates cell propagation and immune escape in acute myeloid leukemia cells
The authors observed that the mouse cytomegalovirus encoded protein m18 is necessary and sufficient to drive expression of the RAE-1 family of NKG2D ligands. RAE-1 is transcriptionally repressed by histone deacetylase inhibitor 3 (HDAC3) in healthy cells, and m18 relieves this repression by directly interacting with Casein Kinase II and preventing it from activating HDAC3.
proposed that TLR9 regulates the NF-kappaB-NLRP3-IL-1beta pathway negatively in Salmonella-induced NKG2D-mediated intestinal inflammation and plays a critical role in defense against S. typhimurium infection and in the protection of intestinal integrity.
NKG2D-deficient mice and mice constitutively expressing NKG2D ligands had increased incidence of B cell tumors, confirming that the inability to clear NKG2D ligand-expressing cells was important in tumor suppression and that NKG2D ligand expression is a marker of nascent tumors
data show that NKG2D has a nonredundant role in priming of CD8(+) T cells to produce antiviral cytokines
NKG2D augments Ly49H-dependent proliferation of NK cells; however, NKG2D signaling alone is inadequate for expansion of NK cells, likely due to only transient expression of the NKG2D-DAP12 complex
expression on intraepithelial lymphocytes and relation to adaptive intestinal immune system
The effect of Bacillus cereus on the stress response of enterocytes, including the expression of NKG2D, is reported.
Determined expressions of NKG2D in decidual natural killer cells in patients having spontaneous abortions.
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
killer cell lectin-like receptor subfamily K, member 1
, NKG2-D type II integral membrane protein-like
, NK cell receptor D
, NKG2-D type II integral membrane protein
, NKG2-D-activating NK receptor
, natural killer cell group 2D
, NK lectin-like receptor
, NKR-P2, ortholog of human NKG2D
, killer cell lectin-like receptor subfamily K member 1
, NKG2-D activating NK receptor