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Human Polyclonal PELI1 Primary Antibody for IHC (p), WB - ABIN252617
Ceppi, Pereira, Dunand-Sauthier, Barras, Reith, Santos, Pierre: MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. in Proceedings of the National Academy of Sciences of the United States of America 2009
Show all 2 Pubmed References
This study demonstrates Pellino 1 (PELI1) as an important modulator that exerts opposite regulatory functions on apoptosis and necroptosis, two distinct forms of regulated cell death mechanisms.
The study demonstrates that cytosolic Pellino-1-mediated K63-linked ubiquitination of IRF5 (show IRF5 Antibodies) in M1 macrophages regulates glucose intolerance in obesity, suggesting a cytosolic mediator function of Pellino-1 in TLR4 (show TLR4 Antibodies)/IFN-gamma (show IFNG Antibodies) receptor-IRF5 (show IRF5 Antibodies) axis during M1 polarization.
Pellino 1 expression acts as an inhibitory signal of the homeostatic regulation of mitotic cell cycle and checkpoint, and thus contributes to the initiation and progression of neoplastic chromosome aneuploidy.
Pellino-1 overexpression activated PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) and ERK (show EPHB2 Antibodies) signaling pathways and elicited an epithelial-mesenchymal transition (EMT (show ITK Antibodies)) phenotype of lung adenocarcinoma cells. Pellino-1-mediated EMT (show ITK Antibodies) was demonstrated through morphology, the upregulation of Vimentin (show VIM Antibodies), Slug and Snail (show SNAI1 Antibodies) expression and the downregulation of E-cadherin (show CDH1 Antibodies) and beta-catenin (show CTNNB1 Antibodies) expression.
Results indicate that Pellino-1 contributes to lung oncogenesis through the overexpression of inhibitor of apoptosis protein 2 (cIAP2) and promotion of cell survival and chemoresistance.
Our results suggest that PELI1 might participate in B-cell maturation (show TNFRSF17 Antibodies) or oncogenic activation of aggressive B-cell lymphomas, both during and after germinal center stages
The combination of low Pellino3 levels together with high and inducible Pellino1 expression may be an important determinant of the degree of inflammation triggered upon Toll-like receptor 2 engagement by Helicobacter pylori and/or its components, contributing to Helicobacter pylori-associated pathogenesis by directing the incoming signal toward an NF-kB-mediated proinflammatory response.
Our observations suggested that Peli-1 gene polymorphism rs329498 might contribute to SLE susceptibility in Chinese Han Population.
The study results in the Chinese Han population showed that PELI1 is a member of a constellation of genetic factors that may contribute to the pathogenesis of systemic lupus erythematosus.
Increased PELI1 expression and subsequent induction of BCL6 (show BCL6 Antibodies) promotes lymphomagenesis.
Peli1 is a proangiogenic molecule that acts downstream of VEGF (show VEGFA Antibodies)-Flk-1 (show KDR Antibodies) and restores angiogenesis and enhances skin flap (show ALOX5AP Antibodies) survivability.
a novel miR (show MLXIP Antibodies)-155-Peli1-c-Rel (show NFkBP65 Antibodies) pathway that specifically regulates Tfh cell generation and function.
These findings reveal a novel mechanism that endotoxin tolerance reprograms mitogen-activated protein kinase (show MAPK1 Antibodies) signaling by suppressing Pellino 1-mediated K63-linked ubiquitination of cIAP2 (show BIRC3 Antibodies), K48-linked ubiquitination, and degradation of TRAF3 (show TRAF3 Antibodies).
Pellino1 interacts with the transcription factor Deformed Epidermal Autoregulatory Factor 1 (DEAF1 (show DEAF1 Antibodies)).
Peli1 is a microglia-specific mediator of autoimmune neuroinflammation that works by regulating Traf3 (show TRAF3 Antibodies) degradation
These results demonstrate that the ligands that signal via MyD88 (show MYD88 Antibodies) do not always employ the same protein kinase (show CDK7 Antibodies) to activate Pellino 1 and show that the activiation of NF-kappaB (show NFKB1 Antibodies) and mitogen-activated protein kinases.
Peli1 as a critical factor in the maintenance of peripheral T cell tolerance and demonstrate a previously unknown mechanism of c-Rel (show NFkBP65 Antibodies) regulation.
Pellino-1 protein may have a cellular function distinct from previously identified functions.
IKKepsilon (show IKBKE Antibodies)/TBK1 (show TBK1 Antibodies) mediate the activation of Pellino 1's E3 ligase activity, as well as inducing the transcription of its gene and protein expression in response to TLR3 (show TLR3 Antibodies) and TLR4 (show TLR4 Antibodies) agonists.
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (By similarity).
E3 ubiquitin-protein ligase pellino homolog 1
, pellino homolog 1
, pellino-related intracellular-signaling molecule
, protein pellino homolog 1
, pellino 1
, pellino protein
, pellino E3 ubiquitin protein ligase 1 L homeolog
, pellino E3 ubiquitin protein ligase 1 S homeolog
, pellino homolog 1b