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anti-Mouse (Murine) PELI2 Antibodies:
anti-Human PELI2 Antibodies:
anti-Rat (Rattus) PELI2 Antibodies:
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Pellino 2 plays a critical role for TLR/IL-1R-mediated post-transcriptional control.
Pellino-2 is a tissue-restricted component of a signaling pathway that couples the mouse pelle (show IRAK1 Antibodies)-like kinase/IL-1 (show IL1A Antibodies) receptor-associated kinase protein to IL-1 (show IL1A Antibodies)- or lipopolysaccharide-dependent signaling.
A high-affinity Pellino2 e3 ubiquitin ligase (show MUL1 Antibodies) binding domain is specific for phosphothreonine motifs.
interacts with TRAF6 (show TRAF6 Antibodies) (tumor necrosis factor (show TNF Antibodies) receptor associated factor 6) and TAK1 (transforming growth factor-beta activated kinase 1 (show MAP3K7 Antibodies)); can activate the mitogen activated protein kinase (show MAPK1 Antibodies) pathway
Pellino2 interacts with kinase-active as well as kinase-inactive IRAK1 (show IRAK1 Antibodies) and IRAK4 (show IRAK4 Antibodies)
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Not required for NF-kappa-B activation (By similarity).
E3 ubiquitin-protein ligase pellino homolog 2
, protein pellino homolog 2
, pellino homolog 2