PELI2 antibody (N-Term)

Catalog No. ABIN5517275

The Rabbit Polyclonal anti-PELI2 antibody (ABIN5517275) specifically detects PELI2 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit and Zebrafish (Danio rerio) samples.

Quick Overview for PELI2 antibody (N-Term) (ABIN5517275)

Target: PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PELI2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PELI2 Antibody

Binding Specificity: N-Term

Sequence: STISRFACRI VCDRNEPYTA RIFAAGFDSS KNIFLGEKAA KWKNPDGHMD

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against PELI2. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human PELI2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PELI2

Target: PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))

Alternative Name: PELI2

Background: PELI2 is a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. It is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. It may be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. And it can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.

Protein Interaction Partner: SRPK1, FRYL, CREB3L3, THAP7, ERO1L, DEAF1, LAMC3, PICALM, LTBP3, IRAK1, HNRNPK, FN1, UBC, UBQLN4, IRAK4, TRAF6, NR2C2, BCL10, MYD88, IRAK2,

Protein Size: 420

Gene ID: 57161

NCBI Accession: NP_067078

UniProt: Q9HAT8

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades