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PELI2 antibody (N-Term)

PELI2 Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5517275
  • Target See all PELI2 Antibodies
    PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))
    Binding Specificity
    • 7
    • 3
    • 2
    • 1
    N-Term
    Reactivity
    Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish (Danio rerio)
    Host
    • 11
    • 1
    Rabbit
    Clonality
    • 12
    Polyclonal
    Conjugate
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    This PELI2 antibody is un-conjugated
    Application
    • 12
    • 8
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    STISRFACRI VCDRNEPYTA RIFAAGFDSS KNIFLGEKAA KWKNPDGHMD
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
    Characteristics
    This is a rabbit polyclonal antibody against PELI2. It was validated on Western Blot.
    Purification
    Affinity purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N-terminal region of Human PELI2
    Top Product
    Discover our top product PELI2 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    PELI2 (Pellino Homolog 2 (Drosophila) (PELI2))
    Alternative Name
    PELI2 (PELI2 Products)
    Synonyms
    AW047589 antibody, BB129927 antibody, pellino 2 antibody, pellino E3 ubiquitin protein ligase family member 2 antibody, Peli2 antibody, PELI2 antibody
    Background
    PELI2 is a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. It is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. It may be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. And it can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.

    Protein Interaction Partner: SRPK1, FRYL, CREB3L3, THAP7, ERO1L, DEAF1, LAMC3, PICALM, LTBP3, IRAK1, HNRNPK, FN1, UBC, UBQLN4, IRAK4, TRAF6, NR2C2, BCL10, MYD88, IRAK2,

    Protein Size: 420
    Gene ID
    57161
    NCBI Accession
    NP_067078
    UniProt
    Q9HAT8
    Pathways
    Activation of Innate immune Response, Toll-Like Receptors Cascades
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