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We suggest from those results that Mo25 and Fray operate together or in the same pathway in Drosophila asymmetric processes, and that their function counterbalances Lkb1 (show STK11 Proteins).
Structural comparison indicates that the overall structures of zebrafish and human MO25 are very similar, suggesting that MO25 has conserved functions in the zebrafish.
plays very important oncogenic roles in hepatocellular carcinoma pathogenesis and progression by activating the ERK (show EPHB2 Proteins) signaling pathway
miR (show MLXIP Proteins)-451 directly targets CAB39 and negatively regulates its expression and inhibition of CAB39 contributes to the promoted cell viability and invasion
These data provide molecular understanding of the mechanism by which MO25 isoforms regulates the activity of STE20 (show STK24 Proteins) family protein kinases.
Authors conclude that miR (show MLXIP Proteins)-451 represses glioma in vitro and in vivo, likely through targeting CAB39 directly and inhibiting the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway indirectly.
MO25 is a master regulator of SPAK (show STK39 Proteins)/OSR1 (show OXSR1 Proteins) and MST3 (show STK24 Proteins)/MST4 (show MST4 Proteins)/YSK1 (show STK25 Proteins) protein kinases.
study describes structure of the core heterotrimeric LKB1 (show STK11 Proteins)-STRADalpha-MO25alpha complex, revealing an unusual allosteric mechanism of LKB1 (show STK11 Proteins) activation; structure also reveals how mutations in Peutz-Jeghers syndrome & sporadic cancers impair LKB1 (show STK11 Proteins) function
STRADalpha.MO25alpha complexes containing LKB1 (show STK11 Proteins) variants were equally effective at phosphorylating and activating AMPK (show PRKAA1 Proteins), BRSK1 (show BRSK1 Proteins), and BRSK2 (show BRSK2 Proteins)
These data define a brush border induction pathway downstream of the Lkb1 (show STK11 Proteins)/Strad (show STRADA Proteins)/Mo25 polarization complex, yet separate from other polarity events.
ATP and MO25alpha cooperate to maintain STRADalpha in an "active" closed conformation required for LKB1 (show STK11 Proteins) activation.
Cab39 differentially interacts with WNK4 (show WNK4 Proteins) and SPAK (show STK39 Proteins)/OSR1 (show OSR1 Proteins) to switch the classic two kinase cascade into a signal kinase transduction
Elevated miR (show MLXIP Proteins)-195 targets the LKB1 (show STK11 Proteins)/AMPK (show PRKAA1 Proteins) signaling axis in hypertrophic cardiomyopathy
Quantitative PCR revealed significantly reduced LKB1 (show STK11 Proteins), MO25alpha, and STRADbeta mRNA in LKB1 (show STK11 Proteins)(-/-) muscle. These findings demonstrate that the LKB1 (show STK11 Proteins)-MO25-STRAD (show STRADA Proteins) complex is the principal AMPKK in skeletal muscle.
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).
, calcium-binding protein 39
, calcium binding protein 39
, calcium binding protein 39-like
, calcium-binding protein 39-like
, Cab39 protein
, calcium binding protein, 39 kDa