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loss of blood-brain barrier proteins, inactivation of survival gene expression such as B-cell lymphoma 2 (Bcl-2 (show BCL2 Proteins)) and an increase in inflammatory cytokines in the serum were observed after stroke with CaMKK beta inhibition. We demonstrate that CaMKK beta is neuroprotective in stroke in aged mice
CaMKK2 as a molecular rheostat for insulin (show INS Proteins) action.
CaMKK2 Inhibits C2C12 Myoblasts Proliferation and Differentiation through AMPK (show PRKAA1 Proteins). Overexpression of CaMKK2 Inhibits Muscle Regeneration in Vivo.
the CaMKK-CaMKIalpha (show CAMK1 Proteins) cascade is required for the axonal growth effect of Wnt5a (show WNT5A Proteins) during neuronal polarization.
In summary, we demonstrate a new mechanism of calcium dependent antibacterial strategy in E. coli infected macrophages, which requires autophagy enhancement mediated by activation of CaMKKbeta, ERK (show EPHB2 Proteins), AMPK (show PRKAA1 Proteins) and FoxO1 (show FOXO1 Proteins).
CaMKKbeta exerts protective effects on cardiac adaptive energy pooling against pressure-overload possibly through phosphorylation of AMPK and by upregulation of PGC-1alpha.
Results demonstrated that genetically inhibiting the CaMKK pathway via CaMKKbeta or CaMK IV (show CAMK4 Proteins) is detrimental in the response of female mice to cerebral ischemia
Data (including data from knockout mice) suggest that up-regulation of Camkk1 (show CAMKK1 Proteins) and calcium signaling stimulates muscle growth via up-regulation of mTORC1 (mammalian target of rapamycin (show FRAP1 Proteins) complex 1) signaling and muscle protein biosynthesis.
caCaMKKalpha stimulates glucose uptake additively with insulin (show INS Proteins), and in insulin (show INS Proteins)-resistant muscle, and alters the phosphorylation of TBC1D1 (show TBC1D1 Proteins)/TBC1D4 (show TBC1D4 Proteins).
a novel function for CaMKK2 in bone remodeling and highlight the potential for its therapeutic inhibition as a valuable bone anabolic strategy that also inhibits OC differentiation in the treatment of osteoporosis.
CAMKK2 exhibited the strongest associations with HIV-associated sensory neuropathy (HIV-SN), with two SNPs and six haplotypes predicting SN status in black Southern Africans.
Study used three cognitive tasks and fMRI to provide convergent evidence of a link between the rs1063843 SNP of CAMKK2 and the function of the dorsolateral prefrontal cortex. In addition, this polymorphism was associated with the function of the striatum during a working memory task.
Data suggest that CAMKK2 is highly expressed in high-grade ovarian cancer and ovarian cancer cell lines; CAMKK2 directly activates Akt1 by phosphorylation at Thr-308 in a Ca2+/calmodulin-dependent manner; CAMKK2 knockdown or inhibition decreases Akt1 phosphorylation at Thr-308 and Ser-473. (CAMKK2 = calcium/calmodulin dependent protein kinase kinase 2; AKT1 = AKT serine/threonine kinase 1)
Single nucleotide polymorphism in CAMKK2 gene is associated with pulmonary non-tuberculous mycobacterial disease.
This study showed that the expression level of CAMKK2 could be regulated by promoter methylation. CAMKK2 serves as a prognostic marker in gliomas and could be a potential therapeutic target in gliomas.
For the first time, we showed that rs1063843, a single nucleotide polymorphism located in the CAMKK2 gene, is highly associated with bipolar disorder
Site-directed mutagenesis analysis revealed that Leu(358) in CaMKKbeta/Ile(322) in CaMKKalpha confer, at least in part, a distinct recognition of AMPK (show PRKAA1 Proteins) but not of CaMKIalpha (show CAMK1 Proteins).
Clopidogrel diminishes TNFalpha (show TNF Proteins)-stimulated VCAM-1 (show VCAM1 Proteins) expression at least in part via HO-1 (show HMOX1 Proteins) induction and CaMKKbeta/AMPK (show PRKAA1 Proteins)/Nrf2 (show GABPA Proteins) pathway in endothelial cells.
CaMKK2 (and Nup62 (show NUP62 Proteins)) are required for optimal androgen receptor (show AR Proteins) transcriptional activity in castrate resistant prostate cancer cells.
Silencing of CAMKK2 using siRNA significantly reduced cell proliferation, colony formation and invasion of gastric cancer cells.
the expression, but not the kinase activity, of AMPK (show PRKAA1 Proteins) and CaMKKbeta is necessary for ADP signaling to eNOS (show NOS3 Proteins)
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases.
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1
, protein-tyrosine kinase
, calcium/calmodulin-dependent protein kinase II beta
, calcium/calmodulin-dependent protein kinase kinase 2, beta
, calcium/calmodulin-dependent protein kinase kinase 2-like
, calcium/calmodulin-dependent protein kinase type II subunit beta-like
, caM-KK 1
, caM-KK alpha
, caM-kinase IV kinase
, caM-kinase kinase 1
, caM-kinase kinase alpha
, caMKK 1
, caMKK alpha
, calcium calmodulin dependent protein kinase kinase alpha
, calcium/calmodulin-dependent protein kinase kinase 1
, calcium/calmodulin-dependent protein kinase kinase alpha
, CAMKK beta protein
, caM-KK 2
, caM-KK beta
, caM-kinase kinase 2
, caM-kinase kinase beta
, calcium/calmodulin-dependent protein kinase beta
, calcium/calmodulin-dependent protein kinase kinase 2
, caMKK 2
, caMKK beta
, calcium/calmodulin-dependent protein kinase kinase beta
, Ca+/Calmodulin-dependent protein kinase kinase beta (CaM-kinase kinase beta)
, CaM-kinase kinase beta
, calcium/calmodulin-dependent protein kinase 2 beta