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anti-Human ELAVL1 Antibodies:
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Human Monoclonal ELAVL1 Primary Antibody for ChIP, IP - ABIN577055
Li, Lu, Dai, Torregroza, Hla, Evans: Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1. in Blood 2014
Show all 3 Pubmed References
Human Monoclonal ELAVL1 Primary Antibody for IF, IHC (p) - ABIN560725
Kani, Faca, Hughes, Zhang, Fang, Shahbaba, Luethy, Erde, Schmidt, Pitteri, Zhang, Katz, Gross, Plevritis, McIntosh, Jain, Hanash, Agus, Mallick: Quantitative proteomic profiling identifies protein correlates to EGFR kinase inhibition. in Molecular cancer therapeutics 2012
Human Monoclonal ELAVL1 Primary Antibody for IHC, WB - ABIN2720122
Sung, Chu, Chen, Liao, Lee: Positive regulation of HIF-1A expression by EBV oncoprotein LMP1 in nasopharyngeal carcinoma cells. in Cancer letters 2016
findings demonstrate that AREs mediate miR-155-5p positive regulation of HuR mRNA levels and translation as well as migration in colon cancer cells, suggesting that targeting miR-155-5p and/or Hur might be useful therapeutic strategies against colon cancer metastasis
although HuR stabilizes ARE-containing RNAs, we found that RRM3 counteracts this effect, as shown in a cell-based ARE reporter assay and by qPCR with native HuR mRNA targets containing multiple AUUUA motifs, possibly by competing with RRM12.
the relative expression levels of Kv11.1 C-terminal isoforms are regulated by the RNA-binding HuR and HuD proteins
CCL20, which is regulated by HuR and secreted into the bone microenvironment, enhances the metastatic ability and bone metastasis of breast cancer cells by stimulating cancer cells and osteoblastic cells in both autocrine and paracrine manners.
Ago2 occupancy on mRNAs with and without HuR, and vice versa, is measured by CLIP-seq. Ago2 interacts with HuR at the level of binding. In addition to antagonism, cooperative interactions are observed transcriptome-wide.
Study suggested that c2orf68 is a potential carcinogenesis factor in colorectal cancer (CRC). Furthermore, c2orf68 may have a synergistic effect with HuR in the onset and development of CRC.
HuR mediated overexpression of IAP1 significantly correlates with poor outcomes and early progression of pancreatic cancer.
HuR is a facilitator of pancreatic tumorigenesis, especially in the setting of inflammation.
These results suggest potential involvement of HuR/TTP RNA binding protein axis in regulation of inflammation in endometriosis.
HuR is associated with various urinary tumors biological characteristics. Targeted therapy of HuR may become an attractive treatment strategy. What's more, more preclinical and clinical trials of this targeted strategy are necessary for the treatment of urinary tumors
Negative expression of HuR and Bim correlates with lower EGFR-tyrosine kinase inhibitors sensitivity in tumor tissues obtained from EGFR-mutant nonsmall cell lung cancer patients.
Reduced expression of HuR may be at least partially responsible for the downregulation of SCN5A mRNA expression in ischemic HF. Overexpression of HuR may rescue decreased SCN5A expression and reduce arrhythmic risk in HF
There was no association between cytoplasmic HuR (cHuR) expression and overall prognosis in patients with resected pancreatic ductal adenocarcinoma undergoing adjuvant chemotherapy. Patients with high cHuR-expressing tumors may benefit from 5-fluorouracil (5-FU)-based adjuvant therapy as compared to gemcitabine, whereas those patients with low cHuR appear to have no survival advantage with gemcitabine compared with 5-FU.
Overexpression of AUF1 and HuR is a common finding observed in thyroid malignancy. Analysis of the tissues obtained by surgical resection as demonstrated in this study is comparable to a fine needle aspiration and in combination with AUF1/HuR immuno-analysis may support the conventional immunohistological investigations.
HuR-dependent editing of a new mineralocorticoid receptor splice variant reveals an osmoregulatory loop for sodium homeostasis.
mechanism of RNA recognition employed by HuR
B4GALT1-AS1 recruited HuR to enhance YAP mRNA stability and thus its transcriptional activity
HuR associates with TERC in vitro and in cultured cells. The association of HuR with TERC was required for the maintenance of TERC methylation and hence telomerase activity. Additionally, the regulation of telomerase activity by HuR was found to impact on the renewal of hematopoietic stem cells and was linked to dyskeratosis congenita, aplastic anemia, and autosomal dominant dyskeratosis congenita.
this study identified an essential Jun/miR-22/HuR regulatory axis in CRC (the working model is summarised in Fig. 8) and highlighted the vital role of HuR and miR-22 in CRC proliferation and migration.
RNA immunoprecipitation and RNA pull-down assays in glioma cell lines demonstrated that SNHG12 was associated with and was stabilized by Hu antigen R. Glioma patients with high levels of SNHG12 exhibited a reduced 5-year overall survival rate.
STAU1 & STAU2 & ELAVL1 mRNAs & proteins were detected throughout cow preimplantation development from the germinal vesicle (GV) oocyte to the blastocyst stage; ELAVL2 mRNAs were detectable from the GV to the morula stage; ELAVL2 protein was in all stages
this study reveals a posttranscriptional regulatory mechanism by which RNA-binding protein Elavl1a regulates embryonic erythropoiesis by maintaining appropriate levels of gata1 expression.
this study shows that endothelial HuR deletion reduces the expression of proatherogenic molecules and attenuates atherosclerosis
Hur expression in the pancreas.HuR is a facilitator of pancreatic tumorigenesis, especially in the setting of inflammation.
Ectopic expression of HuR in astrocytes worsens outcome after transient ischemic stroke in mice in part by increasing vasogenic cerebral edema
Hu antigen R (HuR), dictates translation specificity of bound mRNAs and is sufficient to define distinct Foxp-characterized subpopulations of neocortical projection neurons. Distinct phosphorylation states of HuR differentially regulate translation of Foxp mRNAs in vitro.
Data report that HuR negatively regulates CUGBP1 expression by relocalization to the cytoplasm from the nucleus, which is controlled by different post-transcriptional phosphorylation signaling pathways. These results suggest that HuR acts upstream of CUGBP1 in regulating the expression of genes related to acute myocardial infarction.
Depletion of CLPABP disturbed the normal subcellular localization of HuR to stress granules, and overexpression of CLPABP induced instability of leptin mRNA by inhibiting HuR function.
Data (including data from studies using knockout mice or cells from knockout mice) suggest HuR post-transcriptionally regulates Ccr6 expression by binding to and stabilizing Ccr6 mRNA and by promoting Ccr6 translation in helper T-cells; knock-out of HuR reduces Ccr6 expression on helper T-cells, impairs their migration to CNS, and prevents experimental autoimmune encephalomyelitis. (Ccr6 = C-C chemokine receptor type 6)
Taken together, our results indicate that HuR activation is an early event in familial adenomatosis polyposis (FAP)--adenoma but is not present in inflammatory bowel disease (IBD)-dysplasia. Furthermore, our results offer a preclinical proof of concept for HuR inhibition as an effective means of FAP chemoprevention, with caution advised in the setting of IBD
findings indicate a previously unknown interaction between GSK3beta and ELAV-1 during acute respiratory distress syndrome , and suggest the inhibition of the ELAV-1- GSK3beta pathways as a novel acute respiratory distress syndrome treatment approach.
HuR plays a central role in regulating nuclear import of proteins.
These results indicate that HuR promotes early intestinal mucosal repair after injury by increasing Cdc42 translation.
This study uncovers an anti-sense lncRNA (APOA4-AS), which is co-expressed with APOA4, and concordantly and specifically regulates APOA4 expression both in vitro and in vivo with the involvement of HuR.
These results suggest that the post-transcriptional regulation of ATX expression by HuR and AUF1 modulates cancer cell migration.
Results show that HuR is a key regulator of many genes that make up the molecular signature of activated microglia, including increased production of proinflammatory cytokines, chemokines, and migration-associated factors
Results indicate that HuR induces 14-3-3zeta translation via interaction with its 3' UTR and that 14-3-3zeta is necessary for stimulation of intestinal epithelial cell migration after wounding.
Knockdown of endogenous HuR protein abrogates the IL-1beta-mediated increase in xCT mRNA half-life.
The current data suggested that miR-291b-3p contributed to NCTC1469 cell apoptosis by regulating the expression of HuR, which in turn increased Bcl-2 stability.
HuR may regulate genes in multiple canonical pathways involved in T cell activation especially the CD28 family signaling pathway.
HuR acts as a specialized controller of oxidative metabolism in neurons to confer protection from neurodegeneration.
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.
ELAV-like protein 1
, Hu antigen R
, embryonic lethal, abnormal vision, drosophila, homolog-like 1
, hu-antigen R
, ELAV like 1
, ELAV-like 1 (Hu antigen R)
, elav-related A
, embryonic lethal, abnormal vision-related A
, ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
, HU-antigen A
, elav-like generic protein