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anti-Human ELAVL1 Antibodies:
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Human Monoclonal ELAVL1 Primary Antibody for ChIP, IP - ABIN577055
Li, Lu, Dai, Torregroza, Hla, Evans: Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1. in Blood 2014
Show all 3 Pubmed References
Human Monoclonal ELAVL1 Primary Antibody for IF, IHC (p) - ABIN560725
Kani, Faca, Hughes, Zhang, Fang, Shahbaba, Luethy, Erde, Schmidt, Pitteri, Zhang, Katz, Gross, Plevritis, McIntosh, Jain, Hanash, Agus, Mallick: Quantitative proteomic profiling identifies protein correlates to EGFR kinase inhibition. in Molecular cancer therapeutics 2012
Human Monoclonal ELAVL1 Primary Antibody for IHC, WB - ABIN2720122
Sung, Chu, Chen, Liao, Lee: Positive regulation of HIF-1A expression by EBV oncoprotein LMP1 in nasopharyngeal carcinoma cells. in Cancer letters 2016
this study shows that upregulation of miR-324-5p inhibits proliferation and invasion of colorectal cancer cells by targeting ELAVL1
A structural model of RNA recognition involving all three RRM domains of full-length HuR.
Novel role of HuR in controlling the process of cellular senescence by regulating TIN2-mediated mitochondrial reactive oxygen species production.
interaction of HuR and miR-466i orchestrates GM-CSF expression in Th17 cells
We conclude that MIR100HG potentially serves as a binding platform for both HuR and its target mRNAs, thus modulating HuR-target mRNA interaction
These results show that HuR modulates inflammatory responses by regulating IL-6.
The expression of HuR in adipose tissue is reduced in obese humans.
The data presented herein demonstrate that the P-glycoprotein mRNA transcript is regulated by cooperation between miR-19b and the RNA-binding protein HuR.
findings demonstrate that AREs mediate miR-155-5p positive regulation of HuR mRNA levels and translation as well as migration in colon cancer cells, suggesting that targeting miR-155-5p and/or Hur might be useful therapeutic strategies against colon cancer metastasis
although HuR stabilizes ARE-containing RNAs, we found that RRM3 counteracts this effect, as shown in a cell-based ARE reporter assay and by qPCR with native HuR mRNA targets containing multiple AUUUA motifs, possibly by competing with RRM12.
the relative expression levels of Kv11.1 C-terminal isoforms are regulated by the RNA-binding HuR and HuD proteins
CCL20, which is regulated by HuR and secreted into the bone microenvironment, enhances the metastatic ability and bone metastasis of breast cancer cells by stimulating cancer cells and osteoblastic cells in both autocrine and paracrine manners.
Ago2 occupancy on mRNAs with and without HuR, and vice versa, is measured by CLIP-seq. Ago2 interacts with HuR at the level of binding. In addition to antagonism, cooperative interactions are observed transcriptome-wide.
Study suggested that c2orf68 is a potential carcinogenesis factor in colorectal cancer (CRC). Furthermore, c2orf68 may have a synergistic effect with HuR in the onset and development of CRC.
HuR mediated overexpression of IAP1 significantly correlates with poor outcomes and early progression of pancreatic cancer.
HuR is a facilitator of pancreatic tumorigenesis, especially in the setting of inflammation.
These results suggest potential involvement of HuR/TTP RNA binding protein axis in regulation of inflammation in endometriosis.
HuR is associated with various urinary tumors biological characteristics. Targeted therapy of HuR may become an attractive treatment strategy. What's more, more preclinical and clinical trials of this targeted strategy are necessary for the treatment of urinary tumors
Negative expression of HuR and Bim correlates with lower EGFR-tyrosine kinase inhibitors sensitivity in tumor tissues obtained from EGFR-mutant nonsmall cell lung cancer patients.
Reduced expression of HuR may be at least partially responsible for the downregulation of SCN5A mRNA expression in ischemic HF. Overexpression of HuR may rescue decreased SCN5A expression and reduce arrhythmic risk in HF
STAU1 & STAU2 & ELAVL1 mRNAs & proteins were detected throughout cow preimplantation development from the germinal vesicle (GV) oocyte to the blastocyst stage; ELAVL2 mRNAs were detectable from the GV to the morula stage; ELAVL2 protein was in all stages
this study reveals a posttranscriptional regulatory mechanism by which RNA-binding protein Elavl1a regulates embryonic erythropoiesis by maintaining appropriate levels of gata1 expression.
Data show that a trans-acting factor, RNA binding protein HuR (HuR), which regulate poly(A) binding protein nuclear 1 (Pabpn1) expression specifically in mature muscle in vitro and in vivo.
IL-19 is an atheroprotective cytokine which decreases the abundance of HuR, leading to reduced inflammatory mRNA stability in Ldlr knockout mice.
Compared with control mice, HuR(AKO) mice show obesity when induced with a high-fat diet, along with insulin resistance, glucose intolerance, hypercholesterolemia and increased inflammation in adipose tissue. The obesity of HuR(AKO) mice is attributed to adipocyte hypertrophy in white adipose tissue due to decreased expression of adipose triglyceride lipase (ATGL). HuR positively regulates ATGL expression.
HuR deficiency resulted in the redistribution of TDP43 to cytosolic granules, which has been linked to motor neuron disease. Real-time PCR analysis further indicated that HuR deficiency in neurons resulted in altered expression of genes in the brain involved in cell growth.
this study shows that endothelial HuR deletion reduces the expression of proatherogenic molecules and attenuates atherosclerosis
Hur expression in the pancreas.HuR is a facilitator of pancreatic tumorigenesis, especially in the setting of inflammation.
HuR-dependent editing of a new mineralocorticoid receptor splice variant reveals an osmoregulatory loop for sodium homeostasis.
Ectopic expression of HuR in astrocytes worsens outcome after transient ischemic stroke in mice in part by increasing vasogenic cerebral edema
Hu antigen R (HuR), dictates translation specificity of bound mRNAs and is sufficient to define distinct Foxp-characterized subpopulations of neocortical projection neurons. Distinct phosphorylation states of HuR differentially regulate translation of Foxp mRNAs in vitro.
Data report that HuR negatively regulates CUGBP1 expression by relocalization to the cytoplasm from the nucleus, which is controlled by different post-transcriptional phosphorylation signaling pathways. These results suggest that HuR acts upstream of CUGBP1 in regulating the expression of genes related to acute myocardial infarction.
Depletion of CLPABP disturbed the normal subcellular localization of HuR to stress granules, and overexpression of CLPABP induced instability of leptin mRNA by inhibiting HuR function.
Data (including data from studies using knockout mice or cells from knockout mice) suggest HuR post-transcriptionally regulates Ccr6 expression by binding to and stabilizing Ccr6 mRNA and by promoting Ccr6 translation in helper T-cells; knock-out of HuR reduces Ccr6 expression on helper T-cells, impairs their migration to CNS, and prevents experimental autoimmune encephalomyelitis. (Ccr6 = C-C chemokine receptor type 6)
Taken together, our results indicate that HuR activation is an early event in familial adenomatosis polyposis (FAP)--adenoma but is not present in inflammatory bowel disease (IBD)-dysplasia. Furthermore, our results offer a preclinical proof of concept for HuR inhibition as an effective means of FAP chemoprevention, with caution advised in the setting of IBD
findings indicate a previously unknown interaction between GSK3beta and ELAV-1 during acute respiratory distress syndrome , and suggest the inhibition of the ELAV-1- GSK3beta pathways as a novel acute respiratory distress syndrome treatment approach.
HuR plays a central role in regulating nuclear import of proteins.
These results indicate that HuR promotes early intestinal mucosal repair after injury by increasing Cdc42 translation.
This study uncovers an anti-sense lncRNA (APOA4-AS), which is co-expressed with APOA4, and concordantly and specifically regulates APOA4 expression both in vitro and in vivo with the involvement of HuR.
These results suggest that the post-transcriptional regulation of ATX expression by HuR and AUF1 modulates cancer cell migration.
Results show that HuR is a key regulator of many genes that make up the molecular signature of activated microglia, including increased production of proinflammatory cytokines, chemokines, and migration-associated factors
Results indicate that HuR induces 14-3-3zeta translation via interaction with its 3' UTR and that 14-3-3zeta is necessary for stimulation of intestinal epithelial cell migration after wounding.
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.
ELAV-like protein 1
, Hu antigen R
, embryonic lethal, abnormal vision, drosophila, homolog-like 1
, hu-antigen R
, ELAV like 1
, ELAV-like 1 (Hu antigen R)
, elav-related A
, embryonic lethal, abnormal vision-related A
, ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
, HU-antigen A
, elav-like generic protein