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anti-Human ELAVL1 Antibodies:
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Human Monoclonal ELAVL1 Primary Antibody for ChIP, IP - ABIN577055
Li, Lu, Dai, Torregroza, Hla, Evans: Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1. in Blood 2014
Show all 3 Pubmed References
Human Monoclonal ELAVL1 Primary Antibody for IF, IHC (p) - ABIN560725
Kani, Faca, Hughes, Zhang, Fang, Shahbaba, Luethy, Erde, Schmidt, Pitteri, Zhang, Katz, Gross, Plevritis, McIntosh, Jain, Hanash, Agus, Mallick: Quantitative proteomic profiling identifies protein correlates to EGFR kinase inhibition. in Molecular cancer therapeutics 2012
These results indicate that HuR plays an important role in adenovirus replication, at least in part, by up-regulating IVa2 mRNA expression and that AU-rich element (ARE)-mRNA stabilization is required for both transformation and virus replication.
Data indicate that both ELAVL1 and TIAR positively regulate endogenous SNCA in vivo.
identified HuR as a novel posttranscriptional regulator of ABCA1 (show ABCA1 Antibodies) expression and cellular cholesterol homeostasis, thereby opening new avenues for increasing cholesterol efflux from atherosclerotic foam macrophages and raising circulat-ing HDL (show HSD11B1 Antibodies) cholesterol levels.
HuR expression and cytoplasmic localization were increased in fibrotic livers. S1P (show MBTPS1 Antibodies) induced migration of human bone marrow Mesenchymal Stem Cells via S1PR3 (show S1PR3 Antibodies) and HuR.
RNA-binding protein (show PTBP1 Antibodies) HuR (HuR) expression negatively correlated with chemokine (CC motif) ligand 5 (CCL5 (show CCL5 Antibodies)) expression and macrophage appearance in a cohort of breast tumors.
Data indicate no correlation between RNA-binding protein (show PTBP1 Antibodies) HuR intracellular localization in tumor sections and progression free survival.
our research demonstrated that NEAT1 acts as a key regulator in human ovarian carcinogenesis and revealed two regulatory factors (HuR and miR (show MLXIP Antibodies)-124-3p) of NEAT1 expression.
The crucial role of HuR as a stabilizing factor for the MR transcript.
study found cytoplasmic HuR is significantly overexpressed in higher-grade (atypical and anaplastic) than in lower-grade meningiomas and the HuR level is correlated with survival in patients with meningioma; siHuR-induced HuR knockdown was shown to reduce the growth of both Ben-Men-1 and IOMM-Lee cells
combined treatments of siHuR and epirubicin significantly reduced the expression of Bcl-2 (show BCL2 Antibodies), but increased the expression of Bax (show BAX Antibodies), as well as activity and expression levels of caspase-3 (show CASP3 Antibodies) and -9. In contrast, overHuR abrogated these effects
STAU1 (show STAU1 Antibodies) & STAU2 & ELAVL1 mRNAs & proteins were detected throughout cow preimplantation development (show MTA2 Antibodies) from the germinal vesicle (GV) oocyte to the blastocyst stage; ELAVL2 (show ELAVL2 Antibodies) mRNAs were detectable from the GV to the morula stage; ELAVL2 (show ELAVL2 Antibodies) protein was in all stages
this study reveals a posttranscriptional regulatory mechanism by which RNA-binding protein (show RBM24 Antibodies) Elavl1a regulates embryonic erythropoiesis by maintaining appropriate levels of gata1 (show GATA1 Antibodies) expression.
Depletion of CLPABP disturbed the normal subcellular localization of HuR to stress granules, and overexpression of CLPABP induced instability of leptin (show LEP Antibodies) mRNA by inhibiting HuR function.
Data (including data from studies using knockout mice or cells from knockout mice) suggest HuR post-transcriptionally regulates Ccr6 (show CCR6 Antibodies) expression by binding to and stabilizing Ccr6 (show CCR6 Antibodies) mRNA and by promoting Ccr6 (show CCR6 Antibodies) translation in helper T-cells; knock-out of HuR reduces Ccr6 (show CCR6 Antibodies) expression on helper T-cells, impairs their migration to CNS, and prevents experimental autoimmune encephalomyelitis. (Ccr6 (show CCR6 Antibodies) = C-C chemokine receptor type 6 (show CCR6 Antibodies))
Taken together, our results indicate that HuR activation is an early event in familial adenomatosis polyposis (FAP (show FAP Antibodies))--adenoma but is not present in inflammatory bowel disease (IBD)-dysplasia. Furthermore, our results offer a preclinical proof of concept for HuR inhibition as an effective means of FAP (show FAP Antibodies) chemoprevention, with caution advised in the setting of IBD
findings indicate a previously unknown interaction between GSK3beta and ELAV-1 during acute respiratory distress syndrome , and suggest the inhibition of the ELAV-1- GSK3beta pathways as a novel acute respiratory distress syndrome treatment approach.
HuR plays a central role in regulating nuclear import of proteins.
These results indicate that HuR promotes early intestinal mucosal repair after injury by increasing Cdc42 (show CDC42 Antibodies) translation.
This study uncovers an anti-sense lncRNA (APOA4 (show APOA4 Antibodies)-AS), which is co-expressed with APOA4 (show APOA4 Antibodies), and concordantly and specifically regulates APOA4 (show APOA4 Antibodies) expression both in vitro and in vivo with the involvement of HuR.
These results suggest that the post-transcriptional regulation of ATX (show ENPP2 Antibodies) expression by HuR and AUF1 (show HNRNPD Antibodies) modulates cancer cell migration.
Results show that HuR is a key regulator of many genes that make up the molecular signature of activated microglia, including increased production of proinflammatory cytokines, chemokines, and migration-associated factors
Results indicate that HuR induces 14-3-3zeta (show YWHAZ Antibodies) translation via interaction with its 3' UTR (show UTS2R Antibodies) and that 14-3-3zeta (show YWHAZ Antibodies) is necessary for stimulation of intestinal epithelial cell migration after wounding.
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.
ELAV-like protein 1
, Hu antigen R
, embryonic lethal, abnormal vision, drosophila, homolog-like 1
, hu-antigen R
, ELAV like 1
, ELAV-like 1 (Hu antigen R)
, elav-related A
, embryonic lethal, abnormal vision-related A
, ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
, HU-antigen A
, elav-like generic protein