Browse our anti-PIK3C3 (PIK3C3) Antibodies

Human Phosphoinositide-3-Kinase, Class 3 (PIK3C3) interaction partners

1. Vps34 stimulates tumor development mainly through PKC-delta- activation of p62.

2. Here we show that a putative fifth subunit, nuclear receptor binding factor 2 (NRBF2 (show NRBF2 Antibodies)), is a tightly bound component of the class III phosphatidylinositol 3-kinase complex I that profoundly affects its activity and architecture. NRBF2 (show NRBF2 Antibodies) is a homodimer and drives the dimerization of the larger PI3KC3-C1 complex, with implications for the higher-order organization of the preautophagosomal structure.

3. This study reveals NRBF2 (show NRBF2 Antibodies) as a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation.

4. Atg38 and its human ortholog NRBF2 (show NRBF2 Antibodies), accessory components of complex I consisting of Vps15-Vps34-Vps30/Atg6 (show BECN1 Antibodies)-Atg14 (yeast) and PIK3R4/VPS15-PIK3C3/VPS34-BECN1/Beclin 1 (show BECN1 Antibodies)-ATG14 (human), were characterized.

5. p300 (show EP300 Antibodies)-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed.

6. Low VPS34 expression is associated with cancer.

7. Arf tumor suppressor as a new transcriptional target of nuclear EGFR and highlight Vps34 as an important regulator of the nuclear EGFR/Arf survival pathway.

8. Vps34 has a previously unknown role in regulating Rab7 (show RAB7B Antibodies) activity and late endosomal trafficking.

9. High expression of VPS34 promoted GRP78 (show HSPA5 Antibodies) transcription by modulating ATF6 (show ATF6 Antibodies). VPS34 could enhance GRP78 (show HSPA5 Antibodies) protein stability.

10. These results establish Vps34 as an essential determinant of both short-term and long-term canonical GPCR signaling.

Pig (Porcine) Phosphoinositide-3-Kinase, Class 3 (PIK3C3) interaction partners

1. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.

2. confirmed that the polymorphism in PIK3C3 (C2604T) has the potential to be a genetic marker for production traits in Duroc pigs

Mouse (Murine) Phosphoinositide-3-Kinase, Class 3 (PIK3C3) interaction partners

1. In mouse liver, Vps34 inactivation mildly dampens autophagy, limiting substrate availability for mitochondrial respiration and reducing gluconeogenesis.

2. AP-1 (show JUN Antibodies)/sigma1A (show AP1S1 Antibodies)-ArfGAP1 (show ARFGAP3 Antibodies)-Rabex-5 (show RABGEF1 Antibodies) complex formation leads to more endosomal Rabex-5 (show RABGEF1 Antibodies) and enhanced, Rab5 (show RAB5A Antibodies)(GTP (show AK3 Antibodies))-stimulated Vps34 PI3-kinase (show PIK3CA Antibodies) activity, which is essential for multivesicular body endosome formation.

3. dendritic cells from Vps34-deficient mice have a partially activated phenotype, spontaneously produce cytokines, and exhibit enhanced activity of the classic MHC class I and class II antigen-presentation pathways and displayed a defect in the homeostatic maintenance of splenic CD8alpha(+) dendritic cells and in the capacity of these cells to cross-present cell corpse-associated antigens to MHC class I-restricted T cells.

4. Results demonstrate that Vps34 is essential for proper myelination by Schwann cells. Depletion of PI3P leads to enlarged late endosomal/lysosomal vacuoles and suppressed trafficking in Schwann cells. Suppressed endosomal trafficking likely causes changes in the abundance and post-translational modification of ErbB2 (show ERBB2 Antibodies)/3, a signaling defect that may contribute to arrested myelination in Vps34 deficient nerves.

5. Phosphatidylinositol-3-phosphate is light-regulated, and Vps34 is essential for survival of retinal rod photoreceptor cells.

6. This study reveals NRBF2 (show NRBF2 Antibodies) as a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation.

7. This study uncovers a dual role for Vps34 as a regulator of platelet production by megakaryocytes and as an unexpected regulator of platelet activation and arterial thrombus formation dynamics.

8. E. chaffeensis secretes Etf-1 (show ETF1 Antibodies) to induce autophagy to repurpose the host cytoplasm and capture nutrients for its growth through RAB5 (show RAB5A Antibodies) and class III PtdIns3K, while avoiding autolysosomal killing.

9. p300 (show NOTCH1 Antibodies)-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed.

10. Vps34 has a previously unknown role in regulating Rab7 (show RAB7A Antibodies) activity and late endosomal trafficking.