Browse our anti-PIK3C3 (PIK3C3) Antibodies

Full name:: anti-Phosphoinositide-3-Kinase, Class 3 Antibodies (PIK3C3)

On www.antibodies-online.com are 167 Phosphoinositide-3-Kinase, Class 3 (PIK3C3) Antibodies from 19 different suppliers available. Additionally we are shipping PIK3C3 Proteins (7) and PIK3C3 Kits (6) and many more products for this protein. A total of 185 PIK3C3 products are currently listed.

Synonyms:: 5330434F23Rik, hVps34, im:7147158, Vps34, wu:fc13g06, wu:fz51e12, zgc:112016, zgc:113009

list all antibodies	Gene Name	GeneID	UniProt
	PIK3C3	5289	Q8NEB9
	PIK3C3	65052	O88763
	PIK3C3	225326	Q6PF93
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Most Popular Reactivities for anti-PIK3C3 (PIK3C3) Antibodies

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anti-Human PIK3C3 Antibodies:

anti-Rat (Rattus) PIK3C3 Antibodies:

anti-Mouse (Murine) PIK3C3 Antibodies:

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Relevant Pathways for anti-PIK3C3 Antibodies

Autophagy

More product categories related to PIK3C3 Antibody

Top referenced anti-PIK3C3 Antibodies

Human Polyclonal PIK3C3 Primary Antibody for ICC, IF - ABIN259946 : Huang, Hou, Chen, Zhao, Yan, Zhang, Yang, Kogan, Chen: PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. in Autophagy 2011 (PubMed)
Show all 3 Pubmed References
Human Polyclonal PIK3C3 Primary Antibody for IF (p), IHC (p) - ABIN711686 : Wang, Liang, Lau, Du, Guo, Yan, Gan, Yan, Zhao, Gao, Koch, Ma: Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling. in Autophagy 2017 (PubMed)

More Antibodies against PIK3C3 Interaction Partners

Human Phosphoinositide-3-Kinase, Class 3 (PIK3C3) interaction partners

Vps34 stimulates tumor development mainly through PKC-delta- activation of p62.
Here we show that a putative fifth subunit, nuclear receptor binding factor 2 (NRBF2 (show NRBF2 Antibodies)), is a tightly bound component of the class III phosphatidylinositol 3-kinase complex I that profoundly affects its activity and architecture. NRBF2 (show NRBF2 Antibodies) is a homodimer and drives the dimerization of the larger PI3KC3-C1 complex, with implications for the higher-order organization of the preautophagosomal structure.
This study reveals NRBF2 (show NRBF2 Antibodies) as a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation.
Atg38 and its human ortholog NRBF2 (show NRBF2 Antibodies), accessory components of complex I consisting of Vps15-Vps34-Vps30/Atg6 (show BECN1 Antibodies)-Atg14 (yeast) and PIK3R4/VPS15-PIK3C3/VPS34-BECN1/Beclin 1 (show BECN1 Antibodies)-ATG14 (human), were characterized.
p300 (show EP300 Antibodies)-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed.
Low VPS34 expression is associated with cancer.
Arf tumor suppressor as a new transcriptional target of nuclear EGFR and highlight Vps34 as an important regulator of the nuclear EGFR/Arf survival pathway.
Vps34 has a previously unknown role in regulating Rab7 (show RAB7B Antibodies) activity and late endosomal trafficking.
High expression of VPS34 promoted GRP78 (show HSPA5 Antibodies) transcription by modulating ATF6 (show ATF6 Antibodies). VPS34 could enhance GRP78 (show HSPA5 Antibodies) protein stability.
These results establish Vps34 as an essential determinant of both short-term and long-term canonical GPCR signaling.

Pig (Porcine) Phosphoinositide-3-Kinase, Class 3 (PIK3C3) interaction partners

These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
confirmed that the polymorphism in PIK3C3 (C2604T) has the potential to be a genetic marker for production traits in Duroc pigs

Mouse (Murine) Phosphoinositide-3-Kinase, Class 3 (PIK3C3) interaction partners

Results demonstrate that Vps34 is essential for proper myelination by Schwann cells. Depletion of PI3P leads to enlarged late endosomal/lysosomal vacuoles and suppressed trafficking in Schwann cells. Suppressed endosomal trafficking likely causes changes in the abundance and post-translational modification of ErbB2 (show ERBB2 Antibodies)/3, a signaling defect that may contribute to arrested myelination in Vps34 deficient nerves.
Phosphatidylinositol-3-phosphate is light-regulated, and Vps34 is essential for survival of retinal rod photoreceptor cells.
This study reveals NRBF2 (show NRBF2 Antibodies) as a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation.
This study uncovers a dual role for Vps34 as a regulator of platelet production by megakaryocytes and as an unexpected regulator of platelet activation and arterial thrombus formation dynamics.
E. chaffeensis secretes Etf-1 (show ETF1 Antibodies) to induce autophagy to repurpose the host cytoplasm and capture nutrients for its growth through RAB5 (show RAB5A Antibodies) and class III PtdIns3K, while avoiding autolysosomal killing.
p300 (show NOTCH1 Antibodies)-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed.
Vps34 has a previously unknown role in regulating Rab7 (show RAB7A Antibodies) activity and late endosomal trafficking.
PIK3C3 was strongly expressed in the axon of cortical neurons during brain development.
provide the novel evidence that GADD45A (show GADD45A Antibodies) inhibits autophagy via impairing the BECN1 (show BECN1 Antibodies)-PIK3C3 complex formation
PAQR3 (show PAQR3 Antibodies) controls autophagy by integrating AMPK (show PRKAA1 Antibodies) signaling to enhance ATG14L-associated PI3K activity

PIK3C3 Antigen Profile

Antigen Summary

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis (By similarity).

Alternative names and synonyms associated with PIK3C3

phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) antibody
phosphatidylinositol 3-kinase catalytic subunit type 3 L homeolog (pik3c3.L) antibody
phosphatidylinositol 3-kinase, catalytic subunit type 3 (pik3c3) antibody
phosphatidylinositol 3-kinase, catalytic subunit type 3 (Pik3c3) antibody
phosphatidylinositol 3-kinase catalytic subunit type 3 (Pik3c3) antibody

5330434F23Rik antibody
hVps34 antibody
im:7147158 antibody
Vps34 antibody
wu:fc13g06 antibody
wu:fz51e12 antibody
zgc:112016 antibody
zgc:113009 antibody

Protein level used designations for PIK3C3

phosphoinositide-3-kinase, class 3 , phosphatidylinositol 3-kinase catalytic subunit type 3 , PI3K type 3 , PI3-kinase type 3 , ptdIns-3-kinase type 3 , phosphoinositide-3-kinase class 3 , catalytic phosphatidylinositol 3-kinase 3 , PtdIns-3-kinase type 3 , phosphatidylinositol 3-kinase p100 subunit , class 3 phosphoinositide-3-kinase , PI-3K Vps34p

GENE ID	SPECIES
100053039	Equus caballus
446671	Xenopus laevis
455385	Pan troglodytes
548346	Danio rerio
5289	Homo sapiens
503700	Sus scrofa
65052	Rattus norvegicus
490477	Canis lupus familiaris
534815	Bos taurus
225326	Mus musculus
100857877	Gallus gallus

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Show all anti-Phosphoinositide-3-Kinase, Class 3 (PIK3C3) Antibodies with Pubmed References