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anti-Human PIK3C3 Antibodies:
anti-Rat (Rattus) PIK3C3 Antibodies:
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Human Polyclonal PIK3C3 Primary Antibody for ICC, IF - ABIN259946
Huang, Hou, Chen, Zhao, Yan, Zhang, Yang, Kogan, Chen: PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. in Autophagy 2011
Show all 3 Pubmed References
Vps34 stimulates tumor development mainly through PKC-delta- activation of p62.
Here we show that a putative fifth subunit, nuclear receptor binding factor 2 (NRBF2 (show NRBF2 Antibodies)), is a tightly bound component of the class III phosphatidylinositol 3-kinase complex I that profoundly affects its activity and architecture. NRBF2 (show NRBF2 Antibodies) is a homodimer and drives the dimerization of the larger PI3KC3-C1 complex, with implications for the higher-order organization of the preautophagosomal structure.
This study reveals NRBF2 (show NRBF2 Antibodies) as a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation.
Atg38 and its human ortholog NRBF2 (show NRBF2 Antibodies), accessory components of complex I consisting of Vps15-Vps34-Vps30/Atg6 (show BECN1 Antibodies)-Atg14 (yeast) and PIK3R4/VPS15-PIK3C3/VPS34-BECN1/Beclin 1 (show BECN1 Antibodies)-ATG14 (human), were characterized.
p300 (show EP300 Antibodies)-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed.
Low VPS34 expression is associated with cancer.
Arf (show CDKN2A Antibodies) tumor suppressor as a new transcriptional target of nuclear EGFR (show EGFR Antibodies) and highlight Vps34 as an important regulator of the nuclear EGFR (show EGFR Antibodies)/Arf (show CDKN2A Antibodies) survival pathway.
Vps34 has a previously unknown role in regulating Rab7 (show RAB7B Antibodies) activity and late endosomal trafficking.
High expression of VPS34 promoted GRP78 (show HSPA5 Antibodies) transcription by modulating ATF6 (show ATF6 Antibodies). VPS34 could enhance GRP78 (show HSPA5 Antibodies) protein stability.
These results establish Vps34 as an essential determinant of both short-term and long-term canonical GPCR signaling.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
confirmed that the polymorphism in PIK3C3 (C2604T) has the potential to be a genetic marker for production traits in Duroc pigs
This study uncovers a dual role for Vps34 as a regulator of platelet production by megakaryocytes and as an unexpected regulator of platelet activation and arterial thrombus formation dynamics.
E. chaffeensis secretes Etf-1 (show ETF1 Antibodies) to induce autophagy to repurpose the host cytoplasm and capture nutrients for its growth through RAB5 (show RAB5A Antibodies) and class III PtdIns3K, while avoiding autolysosomal killing.
p300 (show NOTCH1 Antibodies)-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed.
Vps34 has a previously unknown role in regulating Rab7 (show RAB7A Antibodies) activity and late endosomal trafficking.
PIK3C3 was strongly expressed in the axon of cortical neurons during brain development.
provide the novel evidence that GADD45A (show GADD45A Antibodies) inhibits autophagy via impairing the BECN1 (show BECN1 Antibodies)-PIK3C3 complex formation
PAQR3 (show PAQR3 Antibodies) controls autophagy by integrating AMPK (show PRKAA1 Antibodies) signaling to enhance ATG14L-associated PI3K activity
Depletion of hepatic Vps15, the regulatory subunit of class III PI3K, increases insulin (show INS Antibodies) sensitivity and Akt (show AKT1 Antibodies) signaling.
Study identifies a key role of Cul3 (show CUL3 Antibodies)-KLHL20 (show KLHL20 Antibodies) in autophagy termination by controlling autophagy-dependent turnover of ULK1 (show ULK1 Antibodies) and VPS34 complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism.
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis (By similarity).
phosphoinositide-3-kinase, class 3
, phosphatidylinositol 3-kinase catalytic subunit type 3
, PI3K type 3
, PI3-kinase type 3
, ptdIns-3-kinase type 3
, phosphoinositide-3-kinase class 3
, catalytic phosphatidylinositol 3-kinase 3
, PtdIns-3-kinase type 3
, phosphatidylinositol 3-kinase p100 subunit
, class 3 phosphoinositide-3-kinase
, PI-3K Vps34p