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Three polymorphisms (rs2654185, rs5415, and rs5417) in SLC2A4 were positively correlated with hip circumference and the rs2654185 locus was also positively associated with thigh circumference. Consumption of n-3 polyunsaturated fatty acids modifies associations between SCD (show SCD Proteins), SLC2A4, and SREBF1 (show SREBF1 Proteins) polymorphisms and anthropometric variables and metabolic phenotypes.
increased GLUT4 expression in oral squamous cell carcinoma patients was significantly associated with a poor overall survival (OS, P = 0.035) and recurrence-free survival (RFS, P = 0.001). Furthermore, the ectopic overexpression of GLUT4 in cell lines with low endogenous GLUT4 expression resulted in a significant increase in migratory ability both in vitro and in vivo
The results of the study confirmed the presence of GLUT-1 (show SLC2A1 Proteins), GLUT-4 and GLUT-9 proteins in the trophoblast from both, uncomplicated and diabetic pregnancies. In addition, insulin (show INS Proteins) therapy may increase placental expression of GLUT-4 and GLUT-9, and partially GLUT-1 (show SLC2A1 Proteins), in women with pregestational and gestational diabetes mellitus.
our study has found that BMI, hypertension, myometrial invasion, pathological type, and Glut4 positive expression might be prognostic factors of EC [Endometrial cancer ]
Our work highlights the convenience and efficiency of this novel pH-sensitive fluorescent probe and reveals the new biological activity of staurosporine as an agonist for GLUT4 translocation and as an effective insulin (show INS Proteins) additive analogue.
studies demonstrate that Elmo2 (show ELMO2 Proteins) is a new regulator of insulin (show INS Proteins)-dependent Glut4 membrane translocation through modulating Rac1 activity and Akt (show AKT1 Proteins) membrane compartmentalization.
This review focuses on recent advances on the role of these signaling pathways and transcription factors involved in the regulation of CD36 (show CD36 Proteins) and GLUT4.
effects of physiologically relevant phospholipids on glucose transport in liposomes containing purified GLUT4 and GLUT3 (show SLC2A3 Proteins). The anionic phospholipids, phosphatidic acid, phosphatidylserine, phosphatidylglycerol, and phosphatidylinositol, were found to be essential for transporter function by activating it and stabilizing its structure.
These results suggest that the initial event caused by overnutrition may be oxidative stress, which produces insulin (show INS Proteins) resistance, at least in part, via carbonylation and oxidation-induced inactivation of GLUT4.
A single bout of exercise elicited similar GLUT4 translocation in skeletal muscle of PCOS and Controls. The absence of impairment in GLUT4 translocation suggests that PCOS patients with obesity and insulin (show INS Proteins) resistance may benefit from exercise training.
Feed intake remains low whereas respiratory frequency and body temperature remain higher and expression of HSP90 (show HSP90 Proteins), CAT1 (show SLC7A1 Proteins), SGLT1 (show SLC5A1 Proteins) and GLUT4 increases in some tissues in pigs under chronic heat stress conditions.
TBC1D4 (show TBC1D4 Proteins), insulin receptor (show INSR Proteins) and GLUT4 showed altered expression in some tissues in pre-diabetic pigs.
analysis of time- and breed-specific expression patterns of GLUT2 (show SLC2A2 Proteins) and GLUT4, which highlight their potential as candidate genes for assessing adipose deposition and muscle development in pigs
Chronic elevated calcium blocks AMPK (show PRKAA1 Proteins)-induced GLUT-4 expression in skeletal muscle.
Insulin (show INS Proteins) resistance was associated with a significantly reduced total GLUT4 content in omental adipose tissue, without a change in content in other visceral or subcutaneous adipose sites.
There was a significant difference when pooled means for Glut-4 expression in muscle compared with adipose tissue from different anatomical sites.
The disruption of SM22alpha enhances PDGF-BB-induced GLUT4 translocation and glucose uptake by promoting actin dynamics and cortical actin polymeriza- tion.
Data suggest that Glut4 expression is glucose-dependent in white adipocytes; low glucose availability reduces total NADH/NADPH (show FDXR Proteins) levels; high glucose availability up-regulates total NADH/NADPH (show FDXR Proteins) levels, promotes adipogenesis and lipogenesis, and induces Glut4 expression.
Glucose transporter 4 (GLUT4) is required for myocardial adaptations to exercise, and its absence accelerates heart dysfunction after pressure overload.
Data show that TBK1 (show TBK1 Proteins) directly interacts with Exo84 (show EXO84 Proteins) through the coiled-coil domain of TBK1 (show TBK1 Proteins) and helical domain of Exo84 (show EXO84 Proteins), and knockdown of TBK1 (show TBK1 Proteins) blocked insulin (show INS Proteins)-stimulated glucose uptake and GLUT4 translocation.
E4-ORF1 activation of PI3K in adipocytes recapitulates insulin (show INS Proteins) regulation of FoxO1 (show FOXO1 Proteins) but not regulation of Glut4. This uncoupling of PI3K effects occurs despite E4-ORF1 activating PI3K and downstream signaling to levels achieved by insulin (show INS Proteins).
Authors suggest that sortilin (show SORT1 Proteins)- and retromer-mediated Glut4 retrieval from endosomes may represent a step in the Glut4 pathway vulnerable to the development of insulin (show INS Proteins) resistance and diabetes.
It was concluded that ILK (show ILK Proteins) depletion modifies the transcription of GLUT4, which results in reduced peripheral insulin (show INS Proteins) sensitivity and glucose uptake, suggesting ILK (show ILK Proteins) as a molecular target and a prognostic biomarker of insulin (show INS Proteins) resistance.
Data, including data from studies using knockout/transgenic mice, suggest that PrPC (show PRNP Proteins) is involved in development of insulin (show INS Proteins) resistance and obesity; primary embryonic fibroblasts cultured from PrPC (show PRNP Proteins) knockout mice exhibit reduced glucose uptake upon insulin (show INS Proteins) stimulation due to reduced translocation of glucose transporter Glut4 to cell membrane. (PrPC (show PRNP Proteins) = cellular prion protein (show PRNP Proteins); Glut4 = facilitated glucose transporter (show SLC2A12 Proteins) 4)
Our findings implicate Rac1 as a regulatory element critical for controlling glucose uptake during exercise via regulation of GLUT4 translocation.
insulin (show INS Proteins) and insulin (show INS Proteins) resistance regulate the spatial organization of GLUT4 in adipocytes.
Low GLUT1 (show SLC2A1 Proteins) and GLUT3 (show SLC2A3 Proteins) expression in nonclassical monocytes was unaltered during differentiation into macrophages. GLUT4 mRNA was only detectable in unstimulated macrophages. Neither monocytes nor macrophages were insulin (show INS Proteins) responsive.
Results of the present study suggest that myostatin (show MSTN Proteins) inhibits the expression of GLUT4 mRNA and that the greater ability of double muscled cattle to produce muscle may be due to their greater sensitivity to insulin (show INS Proteins) and greater use of glucose.
GLUT4 gene expression increased during late lactation.
These results suggest that goat GLUT4 functions in the transport of glucose and it may play a positive role in amino acid uptake in mammary glands.
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).
, glucose transporter type 4, insulin-responsive
, insulin-responsive glucose transporter type 4
, solute carrier family 2, facilitated glucose transporter member 4
, glucose transporter 4
, glucose transporter type 4
, solute carrier family 2 (facilitated glucose transporter), member 4
, solute carrier family 2, facilitated glucose transporter member 4-like
, Insulin-responsive glucose transporter
, insulin-responsive glucose transporter 4
, insulin-responsive glucose transporter
, Glucose transporter 4 insuline-responsive
, Glucose transporter 4, insuline-responsive
, solute carrier family 2 member 4
, solute carrier family 2 , member 4