Gai2 (Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide-2) antibody
Reactivity: Human
IP, WB
Host: Rabbit
Polyclonal
unconjugated
1 image
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- Target
- Gai2 (Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide-2)
- Reactivity
- Human
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Immunoprecipitation (IP), Western Blotting (WB)
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Storage
- 4 °C
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- Target
- Gai2 (Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide-2)
- Background
- Gai2 is a 40-41 kDa alpha-subunit of heterotrimeric protein, that shares sequence homology with Gai3 and Gai1. All these G proteins can be ADP-ribosylated at the carboxy terminal Cys of the CAAX sequence, interfering with receptor coupling. Gai2 is expressed widely in tissues and cell lines. Activation of PLC-ß by Gai-coupled receptors is the result of release of Gß. subunits from Gai. Gai2regulates potassium channel activation. Mutation at Arg179 has been identified in tumors. This and the Q205L mutant inhibit adenylyl cyclase.
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