UBXN6 antibody

Catalog No. ABIN1381743

Product Details anti-UBXN6 Antibody

Target: UBXN6 (UBX Domain Protein 6 (UBXN6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This UBXN6 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Specificity: Detects both isoforms

No Cross-Reactivity: Mouse (Murine)

Purification: purified

Immunogen: recombinant protein purified from bacteria

Clone: 5C3-1

Isotype: IgG1

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.5 % PBS, 50 % glycerol, 0.1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C

Storage Comment: short term: 2 °C - 8 °C, long term: -20 °C

Target Details for UBXN6

Target: UBXN6 (UBX Domain Protein 6 (UBXN6))

Alternative Name: UBXD1 (Full Length and Short Isoform) (UBXN6 Products)

Background: P97 is a highly abundant and conserved member of the AAA family of ATPase. It has been termed an ubiquitin selective chaperone as it functions within the ubiquitin and/or proteasome pathway. p97 does not interact with ubiquitinated substrates on its own, but requires specific adapters that interact with ubiquitinated substrates and p97 and recruits p97 to substrates. One family of adapters contains a UBX domain, which has been shown with certain adapters to function as a p97-binding module. UBXD1 is a UBX domain containing protein and p97 adapter. This adapter is unique in that it does not harbor an ubiquitin association domain and binds p97 via its PUG domain (another p97 binding motif). Two isoforms of UBXD1 are produced in cells, a full-length form of approximately 54 kDa, and an alternatively spliced variant that lacks the amino-terminal translational start site, and encodes a 47 kDa protein that is derived from an internal translational initiation site. UBXD1 expression at the RNA level has been shown to trend lower in poor prognostic cancers, including those of the breast and prostate.

UniProt: Q9BZV1