TAS2R38 antibody (AA 151-250)

Catalog No. ABIN1385568

Product Details anti-TAS2R38 Antibody

Target: TAS2R38 (Taste Receptor, Type 2, Member 38 (TAS2R38))

Binding Specificity: AA 151-250

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAS2R38 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Cross-Reactivity: Human

Predicted Reactivity: Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human T2R38/TAS2R38

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-TAS2R38 antibody (ABIN1385568)

Gaida, Dapunt, Hänsch: "Sensing developing biofilms: the bitter receptor T2R38 on myeloid cells." in: Pathogens and disease, Vol. 74, Issue 3, (2016) (PubMed).

Maurer, Wabnitz, Kahle, Stegmaier, Prior, Giese, Gaida, Samstag, Hänsch: "Tasting Pseudomonas aeruginosa Biofilms: Human Neutrophils Express the Bitter Receptor T2R38 as Sensor for the Quorum Sensing Molecule N-(3-Oxododecanoyl)-l-Homoserine Lactone." in: Frontiers in immunology, Vol. 6, pp. 369, (2015) (PubMed).

Target Details for TAS2R38

Target: TAS2R38 (Taste Receptor, Type 2, Member 38 (TAS2R38))

Alternative Name: T2R38 (TAS2R38 Products)

Background:

Synonyms: PTC, PTC bitter taste receptor, T2R38, T2R61, taste receptor, type 2, member 38, T2R38_HUMAN.

Background: The sense of taste is essential for the survival of organisms. For example, the ability to identify sweet-tasting foods enables animals to seek out food with high nutritive value, whereas the ability to identify bitter substances enables them to avoid the ingestion of potentially harmful substances. A family of integral membrane proteins are involved in taste perception and include T1R, which is involved in sweet taste perception and T2R, which is involved in bitter taste perception. Both types of taste receptors couple to various G proteins to initiate signal transduction cascades. Specifically, T2R38 is expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Variations in T2R38 are associated with the ability to taste the bitter chemical phenylthiocarbamide (PTC), also called thiourea tasting.

Gene ID: 5726