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NOS1AP antibody (Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein) AA 128-170 (Alexa Fluor 350) Primary Antibody

NOS1AP Reactivity: Human IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 350
Catalog No. ABIN1394493
$476.30
Plus shipping costs $45.00
100 μL
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  • Target See all NOS1AP Antibodies
    NOS1AP
    Binding Specificity
    • 14
    • 9
    • 8
    • 8
    • 7
    • 7
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 128-170
    Reactivity
    • 54
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 45
    • 7
    • 3
    Rabbit
    Clonality
    • 54
    • 1
    Polyclonal
    Conjugate
    • 21
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NOS1AP antibody is conjugated to Alexa Fluor 350
    Application
    • 30
    • 28
    • 16
    • 12
    • 12
    • 11
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Cow,Sheep,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CAPON
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C/-80 °C
    Storage Comment
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Expiry Date
    12 months
  • Target
    NOS1AP
    Alternative Name
    CAPON (NOS1AP Products)
    Synonyms
    MGC78853, Capon, MGC145362, 6330408P19Rik, CAPON, nitric oxide synthase 1 adaptor protein, nitric oxide synthase 1 adaptor protein L homeolog, nitric oxide synthase 1 (neuronal) adaptor protein a, carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, chromosome 18 C1orf226 homolog, nitric oxide synthase 1 (neuronal) adaptor protein, NOS1AP, nos1ap.L, nos1apa, LOC609484, nos1ap, LOC100058633, C18H1orf226, Nos1ap
    Background

    CAPON (carboxy-terminal PDZ ligand of nNOS) selectively binds within the 100 amino acid PDZ domain of the neuronal nitric oxide synthase (nNOS), but not to endothelial NOS or inducible NOS, and sequesters nNOS in the cytosol. Biosynthesis of the neurotransmitter nitric oxide (NO) requires the association of nNOS with various synaptic proteins, including syntrophin, postsynaptic density (PSD)95 and PSD93 through a scaffolding PDZ domain. These proteins facilitate the transport of nNOS to the plasma membrane, where it is catalytically activated by NMDA-receptor mediated calcium channels. The association of nNOS with PSD95 or PSD93 is regulated by CAPON. The carboxy terminus of CAPON binds to the PDZ domain, competes with PSD95 and PSD93 for binding to nNOS and in turn prevents the translocation and catalytic activation of nNOS.

    Subcellular location: Cytoplasm, Nucleus, Cell membrane

    Synonyms: NOS1AP, C terminal PDZ domain ligand of neuronal nitric oxide synthase CAPON, C terminal PDZ domain ligand of neuronal nitric oxide synthase, C terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, CAPON, CAPON_HUMAN, Carboxyl terminal PDZ ligand of neuronal nitric oxide synthase protein, Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, Ligand of neuronal nitric oxide synthase with carboxyl terminal PDZ domain, MGC138500, Nitric oxide synthase 1 neuronal adaptor protein, Nitric oxide synthase 1 adaptor protein.

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