This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012].
Subcellular location: Extracellular
Synonyms: Accn4, ACCN4_HUMAN, Acid sensing proton gated ion channel family member 4, Acid sensing ion channel 4, Acid-sensing ion channel 4, Amiloride sensitive cation channel 4, Amiloride sensitive cation channel 4 pituitary, Amiloride sensitive cation channel family member 4 pituitary, Amiloride-sensitive cation channel 4, Amiloride-sensitive cation channel 4, ASIC4, BNAC4, Brain sodium channel 4, pituitary.