EIF4E antibody (Eukaryotic Translation Initiation Factor 4E) AA 121-217 (Alexa Fluor 555)

Catalog No. ABIN1397206

Product Details anti-EIF4E Antibody

Target: EIF4E

Binding Specificity: AA 121-217

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF4E antibody is conjugated to Alexa Fluor 555

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human eIF4E

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C/-80 °C

Storage Comment: Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles

Expiry Date: 12 months

Target Details for EIF4E

Target: EIF4E

Alternative Name: eIF4E (EIF4E Products)

Synonyms: 0260/09, 0587/11, 0589/11, 0919/12, 1004/13, 2, 7238, CBP, CG4035, CT13384, CT39424, CT39426, D-eIF4E, Dmel\\CG4035, Eif4E, Eif4e, IF4E, dEif4e, deIF-4E, deIF4E, eIF 4E, eIF-4E1, eIF-4E2, eIF-4EII, eIF-4e, eIF4E, eIF4E-1, eIF4E-1/2, eIF4E-2, eIF4E1, eIF4EI, eIF4e, eif-4E, eif-4e, eif4e, l(3)07238, l(3)67Af, l(3)S025007, l(3)S026009, l(3)S058711, l(3)S091912, eIF-4E, cbp, eif4f, eif4e1, eif4el1, AUTS19, EIF4E1, EIF4EL1, EIF4F, EG668879, Eif4e-ps, If4e, EIF-4E, eif4e-1, zgc:86680, Eukaryotic initiation factor 4E, eucaryotic initiation factor 6, eukaryotic translation initiation factor 4E, eukaryotic translation initiation factor 4E family member 1B S homeolog, eukaryotic translation initiation factor 4E L homeolog, eukaryotic translation initiation factor 4ea, translation initiation factor eIF4E, eIF-4E, eif6, eif4e, eif4e1b.S, EIF4E, Eif4e, eif4e.L, eif4ea, LOC100533326

Background:

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.

Subcellular location: Cytoplasm

Synonyms: CBP, EIF4F, AUTS19, EIF4E1, EIF4EL1, Eukaryotic translation initiation factor 4E, eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein

Gene ID:

UniProt: P06730

Pathways: BCR Signaling