FBXO11 antibody (AA 65-160) (AbBy Fluor® 555)
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- Target See all FBXO11 Antibodies
- FBXO11 (F-Box Protein 11 (FBXO11))
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Binding Specificity
- AA 65-160
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FBXO11 antibody is conjugated to AbBy Fluor® 555
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Application
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Predicted Reactivity
- Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Chicken
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human FBXO11
- Isotype
- IgG
- Top Product
- Discover our top product FBXO11 Primary Antibody
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anti-F-Box Protein 11 (FBXO11) (AA 744-843) antibody
FBXO11 Reactivity: Human WB, ELISA, IF, IHC (p) Host: Mouse Monoclonal 4C12 unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 65-160) antibodyFBXO11 Reactivity: Human ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) antibodyFBXO11 Reactivity: Human, Mouse WB, IF Host: Rabbit Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 744-844) antibodyFBXO11 Reactivity: Human WB, ELISA, IF, IHC, IHC (p) Host: Mouse Monoclonal 4C12 unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 1-843) antibodyFBXO11 Reactivity: Human WB, IF Host: Mouse Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (Internal Region) antibodyFBXO11 Reactivity: Human, Mouse, Rat WB, ELISA, ICC Host: Rabbit Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (Middle Region) antibodyFBXO11 Reactivity: Human, Mouse, Rat, Horse, Zebrafish (Danio rerio), Dog, Guinea Pig, Rabbit WB, ChIP Host: Rabbit Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 181-453) antibodyFBXO11 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (AA 754-765) antibodyVerified FBXO11 Reactivity: Human WB, ELISA Host: Goat Polyclonal unconjugated
anti-F-Box Protein 11 (FBXO11) (C-Term) antibodyFBXO11 Reactivity: Human, Mouse, Rat, Horse, Zebrafish (Danio rerio), Dog, Guinea Pig, Rabbit, Xenopus laevis, Chicken, Pig, Bat, Monkey WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- FBXO11 (F-Box Protein 11 (FBXO11))
- Alternative Name
- FBXO11 (FBXO11 Products)
- Background
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Synonyms: UBR6, VIT1, FBX11, PRMT9, UG063H01, F-box only protein 11, Protein arginine N-methyltransferase 9, Vitiligo-associated protein 1, VIT-1, FBXO11
Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
- Gene ID
- 80204
- UniProt
- Q86XK2
- Pathways
- Sensory Perception of Sound
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