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FBXO11 antibody (F-Box Protein 11) AA 65-160 (Alexa Fluor 555) Primary Antibody

FBXO11 Reactivity: Human IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 555
Catalog No. ABIN1399289
$476.30
Plus shipping costs $45.00
100 μL
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  • Target See all FBXO11 Antibodies
    FBXO11
    Binding Specificity
    • 14
    • 9
    • 8
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 65-160
    Reactivity
    • 64
    • 19
    • 16
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 56
    • 7
    • 1
    Rabbit
    Clonality
    • 59
    • 5
    Polyclonal
    Conjugate
    • 29
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FBXO11 antibody is conjugated to Alexa Fluor 555
    Application
    • 39
    • 27
    • 12
    • 12
    • 8
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FBXO11
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C/-80 °C
    Storage Comment
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Expiry Date
    12 months
  • Target
    FBXO11
    Alternative Name
    FBXO11 (FBXO11 Products)
    Synonyms
    FBX11, PRMT9, UBR6, VIT1, C80048, Jf, Vit1, fbxo11, MGC84634, FBXO11, im:6906507, wu:fj83f06, zgc:153171, Fbxo11, DKFZp459P2410, F-box protein 11, F-box protein 11 L homeolog, F-box protein 11a, F-box only protein 11, hypothetical protein, FBXO11, Fbxo11, fbxo11.L, fbxo11a, CpipJ_CPIJ009919, CpipJ_CPIJ017549, Bm1_52225, LOAG_16571, fbxo11, LOC100115478
    Background

    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.

    Subcellular location: Nucleus

    Synonyms: UBR6, VIT1, FBX11, PRMT9, UG063H01, F-box only protein 11, Protein arginine N-methyltransferase 9, Vitiligo-associated protein 1, VIT-1, FBXO11

    Gene ID
    UniProt
    Q86XK2
    Pathways
    Sensory Perception of Sound
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