FBXO11 antibody (F-Box Protein 11) AA 65-160 (Alexa Fluor 555)

Catalog No. ABIN1399289

Product Details anti-FBXO11 Antibody

Target: FBXO11

Binding Specificity: AA 65-160

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXO11 antibody is conjugated to Alexa Fluor 555

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FBXO11

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C/-80 °C

Storage Comment: Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles

Expiry Date: 12 months

Target Details for FBXO11

Target: FBXO11

Alternative Name: FBXO11 (FBXO11 Products)

Synonyms: FBX11, PRMT9, UBR6, VIT1, C80048, Jf, Vit1, fbxo11, MGC84634, FBXO11, im:6906507, wu:fj83f06, zgc:153171, Fbxo11, DKFZp459P2410, F-box protein 11, F-box protein 11 L homeolog, F-box protein 11a, F-box only protein 11, hypothetical protein, FBXO11, Fbxo11, fbxo11.L, fbxo11a, CpipJ_CPIJ009919, CpipJ_CPIJ017549, Bm1_52225, LOAG_16571, fbxo11, LOC100115478

Background:

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.

Subcellular location: Nucleus

Synonyms: UBR6, VIT1, FBX11, PRMT9, UG063H01, F-box only protein 11, Protein arginine N-methyltransferase 9, Vitiligo-associated protein 1, VIT-1, FBXO11

Gene ID:

UniProt: Q86XK2

Pathways: Sensory Perception of Sound