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RSAD2 antibody (Radical S-Adenosyl Methionine Domain Containing 2) (Biotin) Primary Antibody

RSAD2 Reactivity: Human, Mouse, Rat IHC (p), WB Host: Rabbit Polyclonal Biotin
Catalog No. ABIN1400227
$453.20
Plus shipping costs $45.00
100 μL
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Delivery in 11 to 16 Business Days
  • Target See all RSAD2 Antibodies
    RSAD2
    Reactivity
    • 40
    • 28
    • 21
    • 8
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 35
    • 6
    • 1
    Rabbit
    Clonality
    • 36
    • 6
    Polyclonal
    Conjugate
    • 27
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RSAD2 antibody is conjugated to Biotin
    Application
    • 28
    • 13
    • 12
    • 9
    • 8
    • 5
    • 3
    • 3
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Viperin/RSAD2
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C
    Expiry Date
    12 months
  • Target
    RSAD2
    Alternative Name
    Viperin (RSAD2 Products)
    Synonyms
    CIG6, RSAD2, 2510004L01Rik, cig33, cig5, vig1, Vig1, Best5, si:ch211-276e8.2, zgc:112342, viperin, rsad2, radical S-adenosyl methionine domain containing 2, viperin, RSAD2, Rsad2, rsad2, vig1
    Background

    RSAD2 is a 361 amino acid protein that is involved in antiviral defense against pathogens such as Hep C, Cytomegalovirus and HIV-1. Localized to the cytosolic side of the endoplasmic reticulum and relocated to the Golgi apparatus upon viral infection, RSAD2 is thought to prevent viral budding by disrupting lipid rafts at the plasma membrane and supporting the Interferon-induced antiviral state of the cell. Additionally, RSAD2 can bind to and inactivate FDPS (an enzyme that is crucial for the synthesis of cholesterol and geranylated and farnesylated proteins), thereby playing a role in lipid synthesis. Overexpression of RSAD2 leads to abnormal lipid accumulation that is associated with atherosclerosis, a chronic inflammatory disease characterized by hardened arteries.

    Synonyms: endoplasmic reticulum-associated, interferon-inducible, cig 33, CIG 5, cig-33, CIG-5, CIG33, CIG5, Cytomegalovirus induced gene 5 protein, Cytomegalovirus-induced gene 5 protein, Radical S-adenosyl methionine domain-containing protein 2, RSAD 2, Rsad2, RSAD2_HUMAN, RSDA-2, VIG 1, vig1, Viperin, Virus inhibitory protein, virus inhibitory protein endoplasmic reticulum associated interferon inducible.

    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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