VGLL4 antibody (Vestigial Like 4) AA 220-270 (Alexa Fluor 555) Primary Antibody
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- Target See all VGLL4 Antibodies
- VGLL4
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Binding Specificity
- AA 220-270
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This VGLL4 antibody is conjugated to Alexa Fluor 555
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Application
- Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human VGLL4
- Isotype
- IgG
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- Application Notes
- IF(IHC-P) 1:50-200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C/-80 °C
- Storage Comment
- Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
- Expiry Date
- 12 months
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- Target
- VGLL4
- Alternative Name
- VGLL4 (VGLL4 Products)
- Synonyms
- DKFZp459C0333, VGL-4, BC048841, vestigial-like family member 4, vestigial like family member 4, Vgll4, VGLL4
- Background
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The transcriptional enhancer factor-1 (TEF-1) family of transcription factors regulate tissue-specific gene expression in muscle and placenta. The mechanism whereby TEF-1 confers tissue specificity depends largely on the interaction of TEF-1 with tissue-specific cofactors. Transcription cofactor Vgl-4 (vestigial-like protein 4) is a 290 amino acid nuclear protein that interacts with TEF-1 and MEF-2. Vgl-4 is the only member of the vestigial-like family that is expressed in heart. Overexpression of Vgl-4 in cardiac myocytes interferes with basal expression and ?-adrenergic receptor-dependent activation of a TEF-1 dependent skeletal ?actin promoter. This suggests that Vgl-4 counteracts ?-adrenergic activation of gene expression in cardiomyocytes. There are two isoforms of Vgl-4 that are produced as a result of alternative splicing events.
Synonyms: Transcription cofactor vestigial like protein 4, Vestigial like protein 4, VGL 4, VGLL4, VGLL4_HUMAN.
- Gene ID
- UniProt
- Q14135