INIP antibody (INTS3 and NABP Interacting Protein) (Alexa Fluor 555)

Details for Product anti-INIP Antibody No. ABIN1403027
Antigen
  • C8H9orf80
  • C9orf80
  • SSBIP1
  • INIP
  • HSPC043
  • MISE
  • SOSSC
  • hSSBIP1
  • 1110054O05Rik
  • 2610312O17Rik
  • AA399876
  • Ssbip1
  • SOSS-C
  • ssbip1
  • zgc:56259
  • zgc:86662
  • c9orf80
  • hspc043-a
  • mise
  • sossc
  • ci080
  • INTS3 and NABP interacting protein
  • ints3 and nabp interacting protein
  • INTS3 and NABP interacting protein S homeolog
  • INIP
  • Inip
  • inip
  • inip.S
Reactivity
Human, Mouse (Murine), Rat (Rattus)
15
14
14
Host
Rabbit
15
Clonality
Polyclonal
Conjugate
This INIP antibody is conjugated to Alexa Fluor 555
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
12
4
4
1
Options
Immunogen KLH conjugated synthetic peptide derived from human SOSSC/C9orf80
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others INIP products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name SOSSC (INIP Antibody Abstract)
Background

The SOSS (Sensor of single-strand DNA) complex consists of multiple proteins that promote DNA repair and G2/M checkpoint downstream of the MRN (Mre11, Rad50 and Nbs1) complex. The complex is composed of SSBP1, INTS3 and C9orf80. Specifically, the SOSS complex binds to ssDNA at DNA lesions that influences diverse endpoints in the cellular DNA damage response. The complex is required for efficient homologous recombination-dependent repair of double-stranded breaks and ATM-dependent signaling pathways. C9orf80, also known as SOSS complex subunit C and Single-stranded DNA-binding protein-interacting protein 1 (SSBIP1), is a 104 amino acid nuclear protein that is a component of the SOSS complex. Upon DNA damage, C9orf80 along with other components of the SOSS complex migrate to the nucleus. There are two isoforms of C9orf80 that are produced as a result of alternative splicing events.

Synonyms: Chromosome 9 open reading frame 80, hSSBIP1, MISE, RP11-276E15.2, Sensor of single-strand DNA complex subunit C, Sensor of ssDNA subunit C, Single-stranded DNA-binding protein-interacting protein 1, SOSS C, SOSS complex subunit C, SOSS-C, SOSSC, SOSSC_HUMAN, SSB-interacting protein 1, Ssbip1, C9orf80.

Application Notes IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months
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