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MIS18 Binding Protein 1 (MIS18BP1) antibody (Alexa Fluor 488)

MIS18BP1 Reactivity: Human, Mouse, Rat WB, IF (p) Host: Rabbit Polyclonal Alexa Fluor 488
Catalog No. ABIN1403662
  • Target See all MIS18 Binding Protein 1 (MIS18BP1) Antibodies
    MIS18 Binding Protein 1 (MIS18BP1)
    Reactivity
    • 18
    • 14
    • 14
    • 1
    Human, Mouse, Rat
    Host
    • 16
    • 2
    Rabbit
    Clonality
    • 18
    Polyclonal
    Conjugate
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Alexa Fluor 488
    Application
    • 18
    • 12
    • 3
    • 2
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human KNL2/C14orf106
    Isotype
    IgG
    Top Product
    Discover our top product MIS18BP1 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    MIS18 Binding Protein 1 (MIS18BP1)
    Alternative Name
    C14orf106 (MIS18BP1 Products)
    Synonyms
    C14orf106 antibody, HSA242977 antibody, KNL2 antibody, M18BP1 antibody, 6720403H11 antibody, C79407 antibody, Knl2 antibody, mKIAA1903 antibody, MIS18 binding protein 1 antibody, MIS18BP1 antibody, Mis18bp1 antibody
    Background

    Synonyms: Chromosome 14 open reading frame 106, HsKNL-2, KIAA1903, Kinetochore-associated protein KNL-2 homolog, M18BP1, Mis18-binding protein 1, MIS18BP1, P243, Putative protein p243 which interacts with transcription factor Sp1, Uncharacterized potential DNA binding protein C14orf106, M18BP_HUMAN.

    Background: C14orf106 is required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. It interacts with SP1. There are two isoforms.Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5 % of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder ?-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14,19) translocations found in a variety of B cell malignancies. The C14orf106 gene product has been provisionally designated C14orf106 pending further characterization.

    Pathways
    Chromatin Binding
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