CYP11A1 antibody (AA 40-320)

Catalog No. ABIN1512804

Product Details anti-CYP11A1 Antibody

Target: CYP11A1 (Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1))

Binding Specificity: AA 40-320

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP11A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: ISTRSPRPFN EIPSPGDNGW LNLYHFWRET GTHKVHLHHV QNFQKYGPIY REKLGNVESV YVIDPEDVAL LFKSEGPNPE RFLIPPWVAY HQYYQRPIGV LLKKSAAWKK DRVALNQEVM APEATKNFLP LLDAVSRDFV SVLHRRIKKA GSGNYSGDIS DDLFRFAFES ITNVIFGERQ GMLEEVVNPE AQRFIDAIYQ MFHTSVPMLN LPPDLFRLFR TKTWKDHVAA WDVIFSKADI YTQNFYWELR QKGSVHHDYR GILYRLLGDS KMSFEDIKAN V

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 40-320 of human CYP11A1 (NP_000772.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:20 - 1:50,IF,1:20 - 1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CYP11A1

Target: CYP11A1 (Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1))

Alternative Name: CYP11A1 (CYP11A1 Products)

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide.,CYP11A1,CYP11A,CYPXIA1,P450SCC,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Cytochromes,Lipases,Cardiovascular,Lipids,CYP11A1

Molecular Weight: 42 kDa/60 kDa

Gene ID: 1583

UniProt: P05108

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process, Cellular Response to Molecule of Bacterial Origin