FLVCR antibody (AA 451-550) (AbBy Fluor® 350)

Catalog No. ABIN1693512

Product Details anti-FLVCR Antibody (AbBy Fluor® 350)

Target: FLVCR (FLVCR1) (Feline Leukemia Virus Subgroup C Cellular Receptor 1 (FLVCR1))

Binding Specificity: AA 451-550

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FLVCR antibody is conjugated to AbBy Fluor® 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FLVCR

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FLVCR

Target: FLVCR (FLVCR1) (Feline Leukemia Virus Subgroup C Cellular Receptor 1 (FLVCR1))

Alternative Name: FLVCR (FLVCR1 Products)

Background:

Synonyms: Feline leukemia virus subgroup C cellular receptor, Feline leukemia virus subgroup C receptor, Feline leukemia virus subgroup C receptor related protein 1, Feline leukemia virus subgroup C receptor-related protein 1, FLVC1_HUMAN, FLVCR 1, FLVCR protein, FLVCR1, hFLVCR.

Background: FLVCR is responsible for the exportation of cytoplasmic heme groups. It is believed that it may protect developing erythroid cells from heme toxicity. Expression of FLVCR in cells will cause susceptibility to FeLV-C (Feline leukemia virus subgroup C) in vitro. FLVCR is found in all hematopoietic tissues, including peripheral blood lymphocytes and fetal liver, and some expression is found in pancreas and kidney. It is down-regulated in haemopoietic progenitor cells undergoing differentiation and hemoglobinization.

Gene ID: 28982

Pathways: Transition Metal Ion Homeostasis