RASA1 antibody (RAS P21 Protein Activator (GTPase Activating Protein) 1) (Cy5)

Details for Product anti-RASA1 Antibody No. ABIN1704347
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
109
56
54
5
2
2
2
2
2
2
1
1
1
Host
Rabbit
88
20
2
1
Clonality
Polyclonal
Conjugate
This RASA1 antibody is conjugated to Cy5
6
5
5
3
3
3
3
3
3
2
2
2
2
2
2
2
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
77
36
25
15
14
9
8
2
1
1
1
1
Options
Immunogen KLH conjugated synthetic peptide derived from human Ras GTPase-activating protein 1
Isotype IgG
Purification Purified by Protein A.
Antigen
Alternative Name Rasa1 (RASA1 Antibody Abstract)
Background

The mammalian c-H-, c-K- and N-Ras proto-oncogenes encode ubiquitously expressed proteins (1,2). p21Ras can exist in either a physiologically quiescent GDP-binding state or a GTP-binding signal-emitting state (3). Oncogenic p21Ras proteins are trapped in the excited signal-emitting state because the mechanism normally employed to delimit their excitation period, hydrolysis of their bound GTP to GDP, is impaired as a result of specific mutations (3). Interaction of p21Ras with GTPase activating protein (GAP) can increase hydrolysis of p21Ras-bound GTP by as much as 1000-fold (4,5). The product of the neurofibromatosis type 1 gene (NF1) has also been shown to exhibit p21Ras GAP activity (6,7), and proteins that stimulate the GTPase activity of three other low molecular weight GTPases, including Rho, Rab 3A and Rap 1, have also been described (8,9).

Synonyms: Ras GAP, CM AVM, CMAVM, DKFZp434N071, GAP, GTPase activating protein, GTPase-activating protein, OTTHUMP00000222390, OTTHUMP00000222391, OTTHUMP00000222392, OTTHUMP00000222393, p120GAP, p120RASGAP, PKWS, Ras GTPase-activating protein 1, RAS p21 protein activator GTPase activating protein 1, Ras p21 protein activator, RASA, RASA1, RASA1_HUMAN, RasGAP, Triphosphatase activating protein.

Gene ID 5921
Pathways Regulation of Actin Filament Polymerization, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals
Application Notes IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months