Supervillin (SVIL) antibody (Cy5)

Details for Product No. ABIN1704357
Antigen
  • sb:cb867
  • svil
  • wu:fd05a09
  • SVIL
  • DKFZp468F0819
  • AU024053
  • B430302E16Rik
  • supervillin a
  • supervillin
  • supervillin, putative
  • svila
  • SVIL
  • LOC5577073
  • CpipJ_CPIJ003700
  • Smp_148580
  • svil
  • Svil
Reactivity
Human, Mouse (Murine), Rat (Rattus)
37
15
14
Host
Rabbit
29
7
1
Clonality
Polyclonal
Conjugate
Cy5
5
5
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
23
12
9
7
5
4
4
4
3
1
Options
Immunogen KLH conjugated synthetic peptide derived from human Supervillin
Isotype IgG
Purification Purified by Protein A.
Antigen
Alternative Name Supervillin (SVIL Antibody Abstract)
Background

Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity).

Subcellular location: Cell membrane

Synonyms: Supervillin, Archvillin, p205/p250, SVIL

Gene ID 6840
UniProt O95425
Application Notes IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months
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