GnRH2 antibody (Gonadotropin-Releasing Hormone 2)

Details for Product anti-GnRH2 Antibody No. ABIN1713515
Target
Reactivity
Human
42
2
2
Host
Rabbit
41
1
Clonality
Polyclonal
Conjugate
This GnRH2 antibody is un-conjugated
4
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
25
17
12
5
4
2
1
Options
Immunogen KLH conjugated synthetic peptide derived from human GNRH2/GnRH II
Isotype IgG
Purification Purified by Protein A.
Target
Alternative Name GNRH2/GnRH II (GnRH2 Antibody Abstract)
Background

Human reproduction is controlled by the hypothalaic-pituitary gonadal axis laid down early in fetal development. Gonadotropin releasing hormone (GnRH), also known as GnRH-associated peptide, luteinizing hormone releasing hormone (LHRH), luliberin or gonadorelin, is a decapeptide that is an important molecule in the hypothalamic-pituitary-gonadal axis control circuit. GnRH is produced by hypothalamic neurons and secreted in a pulsatile manner into the capillary plexus of the medianeminence. GnRH affects the release of lutenizing hormone and follicle stimulating hormone from gonadotropic cells in the anterior pituitary. In addition to hypothalamic GnRH (GnRH I), a second GnRH form (GnRH II) functions primarily in the midbrain. GnRH is expressed in the acrosomal region of human sperm and in the anterior pituitary tissue and cancer cells. Unlike GnRH I, GnRH II is highly expressed outside the brain, particularly in the kidney, bone marrow and prostate, suggesting that it may have multiple functions. GnRH binds to a specific G protein-coupled receptor in the pituitary to regulate synthesis and secretion of gonadotropins.

Synonyms: GnRH II, GnRH-associated peptide 2, GnRH-associated peptide II, gnrh2, GON2_HUMAN, Gonadoliberin II, Gonadotropin-releasing hormone 2, Gonadotropin-releasing hormone II, LH-RH II, Luliberin II, Luteinizing hormone-releasing hormone II, Progonadoliberin 2, Progonadoliberin II.

Gene ID 2797
Pathways Hormone Activity
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months