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TAZ antibody (Tafazzin) (AA 15-70) Primary Antibody

TAZ Reactivity: Human, Mouse, Rat IF (p), IHC (p), WB Host: Rabbit Polyclonal
Pubmed (2)
Catalog No. ABIN1713913
$339.90
Plus shipping costs $45.00
100 μL
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  • Target
    Binding Specificity
    AA 15-70
    Reactivity
    Human, Mouse, Rat
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This TAZ antibody is un-conjugated
    Application
    Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TAZ
    Isotype
    IgG
  • Application Notes
    WB 1:100-1000
    IHC-P 1:100-500
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C
    Expiry Date
    12 months
  • Ukita, Yamaguchi, Ohata, Tamura: "Sclerostin Enhances Adipocyte Differentiation in 3T3-L1 Cells." in: Journal of cellular biochemistry, Vol. 117, Issue 6, pp. 1419-28, 2016 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).

    Sun, Chen, Shi, Qi, Zhao, Zhang: "Prognostic impact of TAZ and ?-catenin expression in adenocarcinoma of the esophagogastric junction." in: Diagnostic pathology, Vol. 9, pp. 125, 2014 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Human).

  • Target
    Alternative Name
    Taz (TAZ Antibody Abstract)
    Background

    Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

    Subcellular location: Cytoplasm, Nucleus

    Synonyms: TAZ, WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif, WWTR1

    Gene ID
    25937
    UniProt
    Q9GZV5
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