TAZ antibody (Tafazzin) (AA 15-70) Primary Antibody
- Binding Specificity
- AA 15-70
- Human, Mouse, Rat
- This TAZ antibody is un-conjugated
- Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
- Purified by Protein A.
- KLH conjugated synthetic peptide derived from human TAZ
- Application Notes
- WB 1:100-1000
- For Research Use only
- 1 μg/μL
- Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- -20 °C
- Storage Comment
- Store at -20°C
- Expiry Date
- 12 months
Ukita, Yamaguchi, Ohata, Tamura: "Sclerostin Enhances Adipocyte Differentiation in 3T3-L1 Cells." in: Journal of cellular biochemistry, Vol. 117, Issue 6, pp. 1419-28, 2016 (PubMed).
Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).
Sun, Chen, Shi, Qi, Zhao, Zhang: "Prognostic impact of TAZ and ?-catenin expression in adenocarcinoma of the esophagogastric junction." in: Diagnostic pathology, Vol. 9, pp. 125, 2014 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Human).
- Ukita, Yamaguchi, Ohata, Tamura: "Sclerostin Enhances Adipocyte Differentiation in 3T3-L1 Cells." in: Journal of cellular biochemistry, Vol. 117, Issue 6, pp. 1419-28, 2016 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).
- Alternative Name
- Taz (TAZ Antibody Abstract)
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Subcellular location: Cytoplasm, Nucleus
Synonyms: TAZ, WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif, WWTR1
- Gene ID