EhpB1 (AA 19-133) antibody

Catalog No. ABIN1724690

Product Details

Target: EhpB1

Binding Specificity: AA 19-133

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Application: Immunohistochemistry (IHC), ELISA, Western Blotting (WB)

Purpose: EhpB1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of EphB1 (aa19-133) expressed in E. Coli.

Clone: 5F10A4

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References

Huynh-Do, Vindis, Liu, Cerretti, McGrew, Enriquez, Chen, Daniel: "Ephrin-B1 transduces signals to activate integrin-mediated migration, attachment and angiogenesis." in: Journal of cell science, Vol. 115, Issue Pt 15, pp. 3073-81, (2002) (PubMed).

Prevost, Woulfe, Tanaka, Brass: "Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 14, pp. 9219-24, (2002) (PubMed).

Target Details

Target: EhpB1

Background:

Description: EhpB1: EPH receptor B1. It is a receptor for ephrin-B family members. Ephrin receptors and their ligands, the ephrins, medate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family.

Aliases: ELK, NET, Hek6, EPHT2, EPHB1

Molecular Weight: 110kDa

Gene ID: 2047

HGNC: 2047

UniProt: P54762