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Fc Receptor (FcRn) antibody Primary Antibody

Reactivity: Human cELISA, FACS, ELISA Host: Mouse Monoclonal ADM31 unconjugated
Pubmed (1)
Catalog No. ABIN1774762
$495.00
Plus shipping costs $45.00
100 μg
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  • Target
    Fc Receptor (FcRn)
    Reactivity
    • 1
    • 1
    Human
    Host
    • 1
    Mouse
    Clonality
    • 1
    Monoclonal
    Application
    Cell-ELISA (cELISA), Flow Cytometry (FACS), ELISA
    Characteristics
    based on recognition of the complete native protein expressed on transfected mammalian cells
    Purification
    Purified, Protein A
    Immunogen
    Antibodies were generated by immunizing mouse FcRn-deficient mice with spleen cells from mice transgenic for human FcRn.
    Clone
    ADM31
    Isotype
    IgG2b
  • Application Notes
    • Flow cytometry: 1.2 μg/10^6 cells
    • ELISA: 1:200 - 1:400
    • CELISA: 1:200 - 1:400
    For each application a titration should be performed to determine the optimal concentration.
    Restrictions
    For Research Use only
  • Buffer
    phosphate buffered saline, pH 7.2
    Handling Advice
    avoid repeated freezing and thawing
    Storage
    4 °C
  • Christianson, Sun, Akilesh, Pesavento, Proetzel, Roopenian: "Monoclonal antibodies directed against human FcRn and their applications." in: mAbs, Vol. 4, Issue 2, pp. 208-16, 2014 (PubMed).

  • Target
    Fc Receptor (FcRn)
    Background
    The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics.
    Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT
    UniProt
    P55899
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