GNA11 antibody (N-Term)

Catalog No. ABIN1881378

Product Details anti-GNA11 Antibody

Target: GNA11 (Guanine Nucleotide Binding Protein (G Protein), alpha 11 (Gq Class) (GNA11))

Binding Specificity: AA 1-30, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNA11 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, M, Pig, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GNA11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GNA11.

Clone: RB30618

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-GNA11 antibody (ABIN1881378)

Zhao, Zou, Li, Li, Wu, Li, Wang, Zheng: "Expression of G-protein subunit ?-14 is increased in human placentas from preeclamptic pregnancies." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 62, Issue 5, pp. 347-54, (2014) (PubMed).

Gavard, Gutkind: "Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q." in: The Journal of biological chemistry, Vol. 283, Issue 44, pp. 29888-96, (2008) (PubMed).

Durchánková, Novotný, Svoboda: "The time-course of agonist-induced solubilization of trimeric G(q)alpha/G(11)alpha proteins resolved by two-dimensional electrophoresis." in: Physiological research / Academia Scientiarum Bohemoslovaca, Vol. 57, Issue 2, pp. 195-203, (2008) (PubMed).

Shankaranarayanan, Thal, Tesmer, Roman, Neubig, Kozasa, Tesmer: "Assembly of high order G alpha q-effector complexes with RGS proteins." in: The Journal of biological chemistry, Vol. 283, Issue 50, pp. 34923-34, (2008) (PubMed).

Luttrell: "Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors." in: Molecular biotechnology, Vol. 39, Issue 3, pp. 239-64, (2008) (PubMed).

Hildebrand, David, Hamid, Mulatz, Garcia, Zamponi, Snutch: "Selective inhibition of Cav3.3 T-type calcium channels by Galphaq/11-coupled muscarinic acetylcholine receptors." in: The Journal of biological chemistry, Vol. 282, Issue 29, pp. 21043-55, (2007) (PubMed).

Target Details for GNA11

Target: GNA11 (Guanine Nucleotide Binding Protein (G Protein), alpha 11 (Gq Class) (GNA11))

Alternative Name: GNA11 (GNA11 Products)

Background: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.

Molecular Weight: 42123

NCBI Accession: NP_002058

UniProt: P29992

Pathways: G-protein mediated Events