RNASE1 antibody (N-Term)

Catalog No. ABIN1881752

Product Details anti-RNASE1 Antibody

Target: RNASE1 (Ribonuclease, RNase A Family, 1 (Pancreatic) (RNASE1))

Binding Specificity: AA 14-42, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNASE1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RNASE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human RNASE1.

Clone: RB42410

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-RNASE1 antibody (ABIN1881752)

DAlessio: "It takes two to flirt with a dimeric RNase." in: Biopolymers, Vol. 91, Issue 12, pp. 989-94, (2009) (PubMed).

Kövér, Bruix, Santoro, Batta, Laurents, Rico: "The solution structure and dynamics of human pancreatic ribonuclease determined by NMR spectroscopy provide insight into its remarkable biological activities and inhibition." in: Journal of molecular biology, Vol. 379, Issue 5, pp. 953-65, (2008) (PubMed).

Cybulski, Wokołorczyk, Jakubowska, Gliniewicz, Sikorski, Huzarski, Debniak, Narod, Lubiński: "DNA variation in MSR1, RNASEL and E-cadherin genes and prostate cancer in Poland." in: Urologia internationalis, Vol. 79, Issue 1, pp. 44-9, (2007) (PubMed).

Target Details for RNASE1

Target: RNASE1 (Ribonuclease, RNase A Family, 1 (Pancreatic) (RNASE1))

Alternative Name: RNASE1 (RNASE1 Products)

Background: This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq].

Molecular Weight: 17644

NCBI Accession: NP_002924, NP_937875, NP_937877, NP_937878

UniProt: P07998