Tumor Protein P53 Binding Protein 2 (TP53BP2) (Internal Region) antibody

Details for Product No. ABIN233802
Target
Binding Specificity
Internal Region
13
10
8
3
3
1
1
1
1
1
1
Reactivity
Human
61
24
21
6
4
3
2
2
2
2
1
1
1
1
1
Host
Rabbit
58
3
Clonality
Polyclonal
Conjugate
Un-conjugated
5
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
40
24
13
7
6
3
2
2
2
1
1
Options
Immunogen This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an sequence of human ASPP2.
Isotype IgG
Characteristics Concentration Definition: by UV absorbance at 280 nm
Target
Alternative Name ASPP2 (TP53BP2 Antibody Abstract)
Background ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins.  ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis.  In contrast, iASPP functionally inactivates p53.  ASPPs may also regulate p63- and p73-mediated apoptosis.  Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3.  Not all cell cycle arrest genes are affected, such as p21.  Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53.  Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.
Synonyms: Apoptosis stimulating of p53 protein 2 antibody, Bbp antibody, Bcl2 binding protein antibody, NY REN 51 antigen antibody, p53 binding protein 2 antibody
Gene ID 7159, 112799849
UniProt Q13625
Application Notes This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 125 kDa in size corresponding to ASPP2 by western blotting in the appropriate cell lysate or extract.
Restrictions For Research Use only
Format Liquid
Concentration 2.4 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Images
Image no. 1 for anti-Tumor Protein P53 Binding Protein 2 (TP53BP2) (Internal Region) antibody (ABIN233802) Western blot using Protein A purified anti-ASPP2 to detect over-expressed ASPP2 in M...