CKMT1A antibody

Catalog No. ABIN2426267

Product Details anti-CKMT1A Antibody

Target: CKMT1A (Creatine Kinase, Mitochondrial 1A (CKMT1A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CKMT1A antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogen: Synthetic peptide of human CKMT1A/CKMT1B

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.8 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Handling Advice: Avoid freeze / thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CKMT1A

Target: CKMT1A (Creatine Kinase, Mitochondrial 1A (CKMT1A))

Alternative Name: CKMT1A (CKMT1A Products)

Background: Acidic-type mitochondrial creatine kinase,CKMT,CKMT1,CKMT1B,Creatine kinase mitochondrial 1 (ubiquitous),Creatine kinase mitochondrial 1B,Creatine kinase U type mitochondrial,Creatine kinase U-type,KCRU,Mia-CK,mitochondrial,U-MtCK,Ubiquitous mitochondrial creatine kinase,UMTCK,Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80 % homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.

NCBI Accession: NP_066270