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CD40 antibody (CD40 Molecule, TNF Receptor Superfamily Member 5) (Extracellular Domain) Primary Antibody

CD40 Reactivity: Human FACS, St, IHC Host: Mouse Monoclonal 5C3 unconjugated
Pubmed (3)
Catalog No. ABIN2451933
$462.31
Plus shipping costs $45.00
100 μg
local_shipping Shipping to: United States
Delivery in 9 to 11 Business Days
  • Target
    CD40
    Binding Specificity
    Extracellular Domain
    • 21
    • 19
    • 17
    • 15
    • 13
    • 12
    • 11
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Reactivity
    Human
    • 238
    • 114
    • 45
    • 13
    • 9
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Host
    Mouse
    • 153
    • 113
    • 50
    • 5
    • 1
    • 1
    Clonality
    Monoclonal
    • 208
    • 112
    • 1
    Conjugate
    This CD40 antibody is un-conjugated
    • 154
    • 30
    • 29
    • 22
    • 13
    • 7
    • 6
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Flow Cytometry (FACS), Stimulation (St), Immunohistochemistry (IHC)
    • 187
    • 107
    • 78
    • 63
    • 48
    • 37
    • 27
    • 22
    • 21
    • 13
    • 12
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Purification
    Purified from serum-free medium by salting-out and ion-exchange chromatography under mild conditions.
    Sterility
    Sterile filtered
    Immunogen
    Recombinant extracellular domain of CD40 Product, Purified from serum-free medium by salting-out and ion-exchange chromatography under mild conditions.
    Clone
    5C3
    Isotype
    IgG1 kappa
  • Application Notes
    1. Flowcytometry
    2. Immunohistochemistry (acetone or zinc-fixed or frozen section, indirect immuno-staining)
    3. Stimulation of proliferation of B cell and dendritic cells. Enhancement of proinflamentory cytokine production in human monocytes,such as TNF-a,IL-6 and IL-8
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol. Azide- and carrier protein-free.
    Preservative
    Azide free
    Storage
    -20 °C
  • Ishida, Kumanogoh, Suzuki, Akahani, Noda, Kikutani: "Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses." in: International immunology, Vol. 15, Issue 8, pp. 1027-34, 2003 (PubMed).

    Yasui, Muraoka, Takaoka-Shichijo, Ishida, Takegahara, Uchida, Kumanogoh, Suematsu, Suzuki, Kikutani: "Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals." in: International immunology, Vol. 14, Issue 3, pp. 319-29, 2002 (PubMed).

    Inui, Kaisho, Kikutani, Stamenkovic, Seed, Clark, Kishimoto: "Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40." in: European journal of immunology, Vol. 20, Issue 8, pp. 1747-53, 1990 (PubMed).

  • Target
    CD40
    Alternative Name
    CD40 (CD40 Antibody Abstract)
    Synonyms
    Bp50, CDW40, TNFRSF5, p50, AI326936, GP39, HIGM1, IGM, IMD3, T-BAM, TRAP, Tnfrsf5, TNFSF5, CD40 molecule, CD40 antigen, CD40, Cd40
    Background
    CD40 is a 45-50- kDa glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. CD40 is specifically expressed on the surface of B cells and specialized antigen-presenting cells such as dendritic cells and macrophages. CD40 interacts with the CD40 ligand (CD154) which is found primarily on T cells, playing a role in both humoral and cell-mediated immune responses. Activation of CD40 on B cells by CD40 ligand causes B cell proliferation, differentiation, immunoglobulin isotype switching, germinal center formation, and stimulation of the humoral memory response. CD40 has been found to mediate a broad variety of immune and inflammatory responses. Within the cell, the CD40 Molecule acts as a transmembrane signal transducer that leads to activation of intracellular kinases and transcription factors.
    UniProt
    P25942
    Pathways
    NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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