Sup35 (AA 494-507), (PSI+ Prion Phenotype) antibody
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- Target
- Sup35
- Binding Specificity
- AA 494-507, PSI+ Prion Phenotype
- Reactivity
- Saccharomyces cerevisiae
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Western Blotting (WB)
- Cross-Reactivity (Details)
- Not tested in other species.
- Characteristics
- Rabbit polyclonal antibody,purified IgG fraction
- Purification
- Purified
- Immunogen
- Synthetic peptide corresponding to a.a. 494-507 of Sup35
- Isotype
- IgG
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- Application Notes
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1) Western blotting: 1,000~2,000 fold dilution.
Not tested for other applications. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 4 mg/mL
- Buffer
- PBS, 50 % glycerol, 0.09 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C/-80 °C
- Storage Comment
- -20 C (For long term storage: -70 C)
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The role of pre-existing aggregates in Hsp104-dependent polyglutamine aggregate formation and epigenetic change of yeast prions." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 9, Issue 8, pp. 685-96, (2004) (PubMed).
: "
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The role of pre-existing aggregates in Hsp104-dependent polyglutamine aggregate formation and epigenetic change of yeast prions." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 9, Issue 8, pp. 685-96, (2004) (PubMed).
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- Target
- Sup35
- Background
- Background: Sup35 protein of S. cerevisiae is the translation termination factor eRF3. The altered conformation of this protein generates the [PSI+] prion phenotype . In this state, a dominant cytoplasmically inherited protein aggregates are formed which sequester the normal function of Sup35 thereby nonsense suppressor phenotype is created . The molecular chaperon Hsp104 is necessary for the formation and maintenance of the aggregates .
- UniProt
- P05453
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