Transferrin antibody (N-Term)

Catalog No. ABIN2476916

Product Details anti-Transferrin Antibody

Target: Transferrin (TF)

Binding Specificity: N-Term

Reactivity: Human, Rat, Pig, Rabbit

Host: Mouse

Clonality: Monoclonal

Conjugate: This Transferrin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Functional Studies (Func)

Specificity: Anti transferrin clone HTF-14 is specific for the N-terminal domain of human transferrin and has been shown to block binding of transferrin to the transferrin receptor (CD71). Clone HTF-14 is not able to recognise receptor bound transferrin. Clone HTF-14 recognises a conformational epitope in a loop of the N lobe of transferrin involving the critical Lys-144 residue, also essential for binding of the N lobe to the transferrin receptor (Mason et al.2009)Transferrin is a 77 kDa plasma protein synthesized by the liver involved with the transport of iron. Each transferrin molecule has two domains, both with facility to carry 2 ferric ions. The iron/transferrin complex is essential for haemoglobin synthesis and certain types of cell division.

Cross-Reactivity: Pig (Porcine), Rabbit, Rat (Rattus)

Characteristics: Purified IgG

Purification: Purified

Immunogen: Purified porcine transferrin

Clone: HTF-14

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Target Details for Transferrin

Target: Transferrin (TF)

Alternative Name: TRANSFERRIN (TF Products)

Gene ID: 7018

UniProt: P02787

Pathways: Transition Metal Ion Homeostasis