Izumo Sperm-Egg Fusion 1 (IZUMO1) antibody

Details for Product No. ABIN2568277
Target
Reactivity
Human
21
2
Host
Rabbit
20
1
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
1
1
1
Application
ELISA, Western Blotting (WB)
16
15
4
2
1
1
1
Options
Immunogen IZUMO1 antibody was raised against an 18 amino acid peptide near the center of human IZUMO1
Blocking Peptide Blocking peptide for this product available: ABIN2566240
Isotype IgG
Specificity IZUMO1 antibody is human specific. At least four isoforms of IZUMO1 are known to exist, this antibody will detect the two longest isoforms.
Purification IZUMO1 antibody is affinity chromatography purified via peptide column.
Target
Alternative Name IZUMO1 (IZUMO1 Antibody Abstract)
Background IZUMO1, a sperm-specific protein, is essential for sperm-egg plasma membrane binding and fusion. It is involved in the fertilization process and in the fusion of the sperm with the egg (1,2). IZUMO1 is expressed as at least four isoforms produced by alternative splicing and contains one Ig-like (immunoglobulin-like) C2-type domain (3). Lack of IZUMO1 in males, due to homozygous mutation in the gene that encodes IZUMO1, results in sterility due to an inability to penetrate the plasma membrane of the egg (4).
Molecular Weight Predicted: 35, 39, 42 kDa

Observed: 52 kDa
Gene ID 284359
NCBI Accession NP_872381
UniProt Q8IYV9
Application Notes IZUMO1 antibody can be used for detection of IZUMO1 by Western blot at 1 - 2 μ,g/mL.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer IZUMO1 antibody is supplied in PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C,4 °C
Storage Comment IZUMO1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.